Literature DB >> 28814482

Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach.

Eunyoung Choi1,2,3, Tyler L Lantz4, Gregory Vlacich5, Theresa M Keeley6, Linda C Samuelson6, Robert J Coffey1,3,7,8,9, James R Goldenring1,2,7,3,8, Anne E Powell4.   

Abstract

OBJECTIVE: Lrig1 is a marker of proliferative and quiescent stem cells in the skin and intestine. We examined whether Lrig1-expressing cells are long-lived gastric progenitors in gastric glands in the mouse stomach. We also investigated how the Lrig1-expressing progenitor cells contribute to the regeneration of normal gastric mucosa by lineage commitment to parietal cells after acute gastric injury in mice.
DESIGN: We performed lineage labelling using Lrig1-CreERT2/+;R26R-YFP/+ (Lrig1/YFP) or R26R-LacZ/+ (Lrig1/LacZ) mice to examine whether the Lrig1-YFP-marked cells are gastric progenitor cells. We studied whether Lrig1-YFP-marked cells give rise to normal gastric lineage cells in damaged mucosa using Lrig1/YFP mice after treatment with DMP-777 to induce acute injury. We also studied Lrig1-CreERT2/CreERT2 (Lrig1 knockout) mice to examine whether the Lrig1 protein is required for regeneration of gastric corpus mucosa after acute injury.
RESULTS: Lrig1-YFP-marked cells give rise to gastric lineage epithelial cells both in the gastric corpus and antrum, in contrast to published results that Lgr5 only marks progenitor cells within the gastric antrum. Lrig1-YFP-marked cells contribute to replacement of damaged gastric oxyntic glands during the recovery phase after acute oxyntic atrophy in the gastric corpus. Lrig1 null mice recovered normally from acute gastric mucosal injury indicating that Lrig1 protein is not required for lineage differentiation. Lrig1+ isthmal progenitor cells did not contribute to transdifferentiating chief cell lineages after acute oxyntic atrophy.
CONCLUSIONS: Lrig1 marks gastric corpus epithelial progenitor cells capable of repopulating the damaged oxyntic mucosa by differentiating into normal gastric lineage cells in mouse stomach. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Entities:  

Keywords:  Lrig1; SPEM; gastric stem/progenitor cell; metaplasia; oxyntic atrophy; parietal cell

Mesh：

Substances：

Year:  2017        PMID： 28814482      PMCID： PMC5815959          DOI： 10.1136/gutjnl-2017-313874

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  36 in total

1.  Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum.

Authors:  Eunyoung Choi; Joseph T Roland; Brittney J Barlow; Ryan O'Neal; Amy E Rich; Ki Taek Nam; Chanjuan Shi; James R Goldenring
Journal:  Gut       Date:  2014-01-31       Impact factor: 23.059

2.  LRIG1 Regulates Ontogeny of Smooth Muscle-Derived Subsets of Interstitial Cells of Cajal in Mice.

Authors:  Jumpei Kondo; Anne E Powell; Yang Wang; Melissa A Musser; E Michelle Southard-Smith; Jeffrey L Franklin; Robert J Coffey
Journal:  Gastroenterology       Date:  2015-04-25       Impact factor: 22.682

3.  Loss of Lrig1 leads to expansion of Brunner glands followed by duodenal adenomas with gastric metaplasia.

Authors:  Yang Wang; Chanjuan Shi; Yuanyuan Lu; Emily J Poulin; Jeffery L Franklin; Robert J Coffey
Journal:  Am J Pathol       Date:  2015-04       Impact factor: 4.307

Review 4.  Gastric epithelial stem cells.

Authors:  Jason C Mills; Ramesh A Shivdasani
Journal:  Gastroenterology       Date:  2010-12-07       Impact factor: 22.682

5.  Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice.

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Journal:  Gastroenterology       Date:  2016-09-23       Impact factor: 22.682

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Authors:  Victoria G Weis; James R Goldenring
Journal:  Gastric Cancer       Date:  2010-01-05       Impact factor: 7.370

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Journal:  Nucleic Acids Res       Date:  2014-10-29       Impact factor: 16.971

10.  The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach.

Authors:  Amy C Engevik; Rui Feng; Eunyoung Choi; Shana White; Nina Bertaux-Skeirik; Jing Li; Maxime M Mahe; Eitaro Aihara; Li Yang; Betsy DiPasquale; Sunghee Oh; Kristen A Engevik; Andrew S Giraud; Marshall H Montrose; Mario Medvedovic; Michael A Helmrath; James R Goldenring; Yana Zavros
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2016-05-17
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3.  Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress.

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Journal:  Cell Stem Cell       Date:  2022-05-05       Impact factor: 25.269

5.  Expression of LRIG1, a Negative Regulator of EGFR, Is Dynamically Altered during Different Stages of Gastric Carcinogenesis.

Authors:  Sungsook Yu; Mijeong Yang; Kyung-Min Lim; Yejin Cho; Hyunji Kim; Keunwook Lee; Sang-Ho Jeong; Robert J Coffey; James R Goldenring; Ki Taek Nam
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6.  Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.

Authors:  Seungmin Han; Juergen Fink; David J Jörg; Eunmin Lee; Min Kyu Yum; Lemonia Chatzeli; Sebastian R Merker; Manon Josserand; Teodora Trendafilova; Amanda Andersson-Rolf; Catherine Dabrowska; Hyunki Kim; Ronald Naumann; Ji-Hyun Lee; Nobuo Sasaki; Richard Lester Mort; Onur Basak; Hans Clevers; Daniel E Stange; Anna Philpott; Jong Kyoung Kim; Benjamin D Simons; Bon-Kyoung Koo
Journal:  Cell Stem Cell       Date:  2019-08-15       Impact factor: 24.633

Review 7.  LRIG1, a regulator of stem cell quiescence and a pleiotropic feedback tumor suppressor.

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Review 9.  Translating Developmental Principles to Generate Human Gastric Organoids.

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