Jennifer Mark1, John Kinuthia, Alison C Roxby, Daisy Krakowiak, Alfred Osoti, Barbra A Richardson, Molly Ann Gone, Victor Asila, Saloni Parikh, Carey Farquhar. 1. From the *Department of Epidemiology, University of Washington, Seattle, WA; †Departments of Research and Programs, ‡Department of Reproductive Health, Kenyatta National Hospital, Nairobi, Kenya; §Department of Obstetrics and Gynaecology, University of Nairobi; Nairobi, Kenya; ¶Departments of Medicine, ∥Global Health, **Biostatistics, and ††Computer Science and Engineering, University of Washington, Seattle, WA.
Abstract
BACKGROUND: Few men are tested for syphilis or human immunodeficiency virus (HIV) during their partner's pregnancy, a high-risk period for HIV and syphilis transmission. Offering home-based rapid testing of syphilis to couples during pregnancy can support prevention efforts to reduce transmission of sexually transmitted diseases and adverse pregnancy outcomes. METHODS: We assessed men's uptake of paired (separate tests, single blood draw) point-of-care syphilis and HIV tests within a randomized controlled trial of pregnant women who received clinic or home partner HIV testing. We evaluated acceptance of paired HIV-syphilis testing during pregnancy or at 6 months postpartum, and evaluated whether addition of syphilis testing affected the uptake of HIV testing among men. RESULTS: Of 601 women, we were unable to meet 101 male partners, and 180 tested before syphilis tests were available. Paired syphilis and HIV testing was offered at home to 80 men during pregnancy and to 230 men postpartum. For syphilis, 93% of men agreed to test during pregnancy and 98% agreed postpartum. For paired syphilis and HIV testing, 91% of men tested for both during pregnancy and 96% tested postpartum. Before syphilis test introduction, 96% of men accepted HIV testing, compared with 95% of men who accepted HIV testing when paired testing was offered. CONCLUSIONS:Uptake of syphilis and HIV testing was high among male partners offered couple testing at home. Introducing syphilis testing did not adversely affect HIV testing among men. Point-of-care diagnostics outside facilities can increase testing of male partners who rarely accompany women to antenatal clinics.
RCT Entities:
BACKGROUND: Few men are tested for syphilis or human immunodeficiency virus (HIV) during their partner's pregnancy, a high-risk period for HIV and syphilis transmission. Offering home-based rapid testing of syphilis to couples during pregnancy can support prevention efforts to reduce transmission of sexually transmitted diseases and adverse pregnancy outcomes. METHODS: We assessed men's uptake of paired (separate tests, single blood draw) point-of-care syphilis and HIV tests within a randomized controlled trial of pregnant women who received clinic or home partner HIV testing. We evaluated acceptance of paired HIV-syphilis testing during pregnancy or at 6 months postpartum, and evaluated whether addition of syphilis testing affected the uptake of HIV testing among men. RESULTS: Of 601 women, we were unable to meet 101 male partners, and 180 tested before syphilis tests were available. Paired syphilis and HIV testing was offered at home to 80 men during pregnancy and to 230 men postpartum. For syphilis, 93% of men agreed to test during pregnancy and 98% agreed postpartum. For paired syphilis and HIV testing, 91% of men tested for both during pregnancy and 96% tested postpartum. Before syphilis test introduction, 96% of men accepted HIV testing, compared with 95% of men who accepted HIV testing when paired testing was offered. CONCLUSIONS: Uptake of syphilis and HIV testing was high among male partners offered couple testing at home. Introducing syphilis testing did not adversely affect HIV testing among men. Point-of-care diagnostics outside facilities can increase testing of male partners who rarely accompany women to antenatal clinics.
Authors: P Gichangi; K Fonck; C Sekande-Kigondu; J Ndinya-Achola; J Bwayo; D Kiragu; P Claeys; M Temmerman Journal: Int J STD AIDS Date: 2000-04 Impact factor: 1.359
Authors: Mary L Kamb; Lori M Newman; Patricia L Riley; Jennifer Mark; Sarah J Hawkes; Tasneem Malik; Nathalie Broutet Journal: Obstet Gynecol Int Date: 2010-07-14
Authors: Gabriela B Gomez; Mary L Kamb; Lori M Newman; Jennifer Mark; Nathalie Broutet; Sarah J Hawkes Journal: Bull World Health Organ Date: 2013-01-17 Impact factor: 9.408
Authors: Adam R Aluisio; Rose Bosire; Betz Bourke; Ann Gatuguta; James N Kiarie; Ruth Nduati; Grace John-Stewart; Carey Farquhar Journal: J Acquir Immune Defic Syndr Date: 2016-10-01 Impact factor: 3.731
Authors: N Saman Wijesooriya; Roger W Rochat; Mary L Kamb; Prasad Turlapati; Marleen Temmerman; Nathalie Broutet; Lori M Newman Journal: Lancet Glob Health Date: 2016-08 Impact factor: 26.763
Authors: Jennifer Mark; John Kinuthia; Alfred O Osoti; Molly A Gone; Victor Asila; Daisy Krakowiak; Monisha Sharma; Saloni Parikh; Quy T Ton; Barbra A Richardson; Carey Farquhar; Alison C Roxby Journal: Sex Transm Dis Date: 2019-11 Impact factor: 2.830
Authors: Zachary Kwena; Liza Kimbo; Lynae A Darbes; Abigail M Hatcher; Anna Helova; George Owino; Harsha Thirumurthy; Elizabeth A Bukusi; Thomas Braun; Meredith Kilgore; Maria Pisu; Ashutosh Tamhane; Van T Nghiem; Kawango Agot; Torsten B Neilands; Janet M Turan Journal: Trials Date: 2021-01-06 Impact factor: 2.279
Authors: Jami L Anderson; Peng Li; Elizabeth A Bukusi; Lynae A Darbes; Abigail M Hatcher; Anna Helova; Zachary A Kwena; Pamela L Musoke; George Owino; Patrick Oyaro; Anna Joy G Rogers; Janet M Turan Journal: AIDS Behav Date: 2020-10-14