Literature DB >> 28809394

SMAD5 signaling: more than meets the nuclei.

John Orlowski1.   

Abstract

SMADs are essential transcriptional effectors of transforming growth factor-β (TGFβ)/TGFβ-related signaling that underlies embryonic development and adult homeostasis. A recent study by Fang et al. in Cell Research adds to this biological complexity by demonstrating an atypical cytoplasmic role for SMAD5 in modulating the bioenergetic homeostasis (i.e., glycolysis and mitochondrial respiration) of cells in response to fluctuations in intracellular pH that is independent of receptor signaling.

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Year:  2017        PMID： 28809394      PMCID： PMC5587846          DOI： 10.1038/cr.2017.101

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  8 in total

Review 1.  Alternative splicing of SMADs in differentiation and tissue homeostasis.

Authors:  Shijie Tao; Karuna Sampath
Journal:  Dev Growth Differ       Date:  2010-04-05       Impact factor: 2.053

Review 2.  Moonlighting proteins: an intriguing mode of multitasking.

Authors:  Daphne H E W Huberts; Ida J van der Klei
Journal:  Biochim Biophys Acta       Date:  2010-02-06

Review 3.  TGFβ signalling in context.

Authors:  Joan Massagué
Journal:  Nat Rev Mol Cell Biol       Date:  2012-09-20       Impact factor: 94.444

4.  Mitochondrial localization of Smad5 in a human chondrogenic cell line.

Authors:  Mia Jüllig; N Susan Stott
Journal:  Biochem Biophys Res Commun       Date:  2003-07-18       Impact factor: 3.575

Review 5.  TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility.

Authors:  Bernhard Schmierer; Caroline S Hill
Journal:  Nat Rev Mol Cell Biol       Date:  2007-12       Impact factor: 94.444

6.  Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion.

Authors:  Sanjay Kumar; Christopher C Pan; Nirav Shah; Sarah E Wheeler; Kari R Hoyt; Nadine Hempel; Karthikeyan Mythreye; Nam Y Lee
Journal:  Mol Cell       Date:  2016-05-12       Impact factor: 17.970

7.  Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation.

Authors:  Bryne Ulmschneider; Bree K Grillo-Hill; Marimar Benitez; Dinara R Azimova; Diane L Barber; Todd G Nystul
Journal:  J Cell Biol       Date:  2016-11-07       Impact factor: 10.539

8.  Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis.

Authors:  Yujiang Fang; Zhongliang Liu; Zhenyu Chen; Xiangjie Xu; Mengtao Xiao; Yanyan Yu; Yuanyuan Zhang; Xiaobai Zhang; Yanhua Du; Cizhong Jiang; Yuzheng Zhao; Yiran Wang; Beibei Fan; Daniel Terheyden-Keighley; Yang Liu; Lei Shi; Yi Hui; Xin Zhang; Bowen Zhang; Hexi Feng; Lin Ma; Quanbin Zhang; Guohua Jin; Yi Yang; Bin Xiang; Ling Liu; Xiaoqing Zhang
Journal:  Cell Res       Date:  2017-07-04       Impact factor: 25.617
  8 in total
  2 in total

1.  Exosomes Derived from SW480-Resistant Colon Cancer Cells Are Promote Angiogenesis via BMP-2/Smad5 Signaling Pathway.

Authors:  Song Yang; Lei Yao; Xiaolong Wang; Hao Sun; Chaogang Du; Chengpeng Song; Jingyu Fu; Yongjun Wu; Hongwu Huang; Chuansi Wang; Yongsen Wang; Yixiang Xie
Journal:  Appl Bionics Biomech       Date:  2022-05-19       Impact factor: 1.664

2.  Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease.

Authors:  Martha Alicia Ballinas-Verdugo; Rogelio Frank Jiménez-Ortega; Eduardo Martínez-Martínez; Nancy Rivas; Erick Abraham Contreras-López; Roxana Carbó; Fausto Sánchez; Rafael Bojalil; Ricardo Márquez-Velasco; Fausto Sánchez-Muñoz; Ricardo Alejandre-Aguilar
Journal:  Biol Res       Date:  2021-07-21       Impact factor: 5.612
  2 in total

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