Literature DB >> 20148926

Alternative splicing of SMADs in differentiation and tissue homeostasis.

Shijie Tao1, Karuna Sampath.   

Abstract

Tissue-specific alternate splicing is an important means of regulating gene expression during development. The effector proteins for the transforming growth factor-beta signaling pathway, the SMADs, encode distinct isoforms generated via alternate splicing, which appear to have distinct tissue-specific expression profiles and functions. Here, we discuss the roles of various SMAD isoforms, and the consequences of mis-regulation of SMAD splicing in development and tissue homeostasis.

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Year:  2010        PMID： 20148926     DOI： 10.1111/j.1440-169X.2009.01163.x

Source DB:  PubMed          Journal:  Dev Growth Differ        ISSN： 0012-1592            Impact factor:   2.053


  14 in total

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