Alex J Mitchell1, Bhavisha Sheth2, John Gill3, Motahare Yadegarfar4, Brendon Stubbs5, Mohammad Yadegarfar6, Nick Meader7. 1. Department of Cancer Studies & Molecular Medicine, Leicester Royal Infirmary, LE1 5WW, UK. Electronic address: ajm80@le.ac.uk. 2. Leicestershire Partnership NHS Trust, UK. Electronic address: bs150@student.le.ac.uk. 3. Leicestershire Partnership NHS Trust, UK. Electronic address: jsg19@student.le.ac.uk. 4. Leicestershire Partnership NHS Trust, UK. Electronic address: my71@student.le.ac.uk. 5. South London and Maudsley NHS Foundation Trust, Denmark Hill, London, UK. Electronic address: brendon.stubbs@kcl.ac.ul. 6. Faculty of Health, Social care and Education, Anglia Ruskin University, Chelmsford, UK. Electronic address: mohammad.yadegarfar@ncl.ac.uk. 7. Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK. Electronic address: nick.meader@york.ac.uk.
Abstract
OBJECTIVE: To ascertain the prevalence and predictors of mood disorders, determined by structured clinical interviews (ICD or DSM criteria) in people after stroke. METHODS: Major electronic databases were searched from inception to June 2016 for studies involving major depression (MDD), minor depression (MnD), dysthymia, adjustment disorder, any depressive disorder (any depressive disorder) and anxiety disorders. Studies were combined using both random and fixed effects meta-analysis and results were stratified as appropriate. RESULTS: Depression was examined on 147 occasions from 2days to 7years after stroke (mean 6.87months, N=33 in acute, N=43 in rehabilitation and N=69 in the community/outpatients). Across 128 analyses involving 15,573 patients assessed for major depressive disorder (MDD), the point prevalence of depression was 17.7% (95% CI=15.6% to 20.0%) 0.65 analyses involving 9720 patients determined MnD was present in 13.1% in all settings (95% CI=10.9% to 15.8%). Dysthymia was present in 3.1% (95% CI=2.1% to 5.3%), adjustment disorder in 6.9% (95% CI=4.6 to 9.7%) and anxiety in 9.8% (95% CI=5.9% to 14.8%). Any depressive disorder was present in 33.5% (95% CI=30.3% to 36.8%). The relative risk of any depressive disorder was higher following left (dominant) hemisphere stroke, aphasia, and among people with a family history and past history of mood disorders. CONCLUSION: Depression, adjustment disorder and anxiety are common after stroke. Risk factors are aphasia, dominant hemispheric lesions and past personal/family history of depression but not time since stroke.
OBJECTIVE: To ascertain the prevalence and predictors of mood disorders, determined by structured clinical interviews (ICD or DSM criteria) in people after stroke. METHODS: Major electronic databases were searched from inception to June 2016 for studies involving major depression (MDD), minor depression (MnD), dysthymia, adjustment disorder, any depressive disorder (any depressive disorder) and anxiety disorders. Studies were combined using both random and fixed effects meta-analysis and results were stratified as appropriate. RESULTS:Depression was examined on 147 occasions from 2days to 7years after stroke (mean 6.87months, N=33 in acute, N=43 in rehabilitation and N=69 in the community/outpatients). Across 128 analyses involving 15,573 patients assessed for major depressive disorder (MDD), the point prevalence of depression was 17.7% (95% CI=15.6% to 20.0%) 0.65 analyses involving 9720 patients determined MnD was present in 13.1% in all settings (95% CI=10.9% to 15.8%). Dysthymia was present in 3.1% (95% CI=2.1% to 5.3%), adjustment disorder in 6.9% (95% CI=4.6 to 9.7%) and anxiety in 9.8% (95% CI=5.9% to 14.8%). Any depressive disorder was present in 33.5% (95% CI=30.3% to 36.8%). The relative risk of any depressive disorder was higher following left (dominant) hemisphere stroke, aphasia, and among people with a family history and past history of mood disorders. CONCLUSION:Depression, adjustment disorder and anxiety are common after stroke. Risk factors are aphasia, dominant hemispheric lesions and past personal/family history of depression but not time since stroke.
Authors: Alyson R Plecash; Amokrane Chebini; Alvin Ip; Joshua J Lai; Andrew A Mattar; Jason Randhawa; Thalia S Field Journal: Curr Neurol Neurosci Rep Date: 2019-11-13 Impact factor: 5.081
Authors: Catherine Minshall; Chantal F Ski; Pragalathan Apputhurai; David R Thompson; David J Castle; Zoe Jenkins; Simon R Knowles Journal: J Clin Psychol Med Settings Date: 2021-03
Authors: Laura C Polding; William J Tate; Michael Mlynash; Michael P Marks; Jeremy J Heit; Soren Christensen; Stephanie Kemp; Gregory W Albers; Maarten G Lansberg Journal: Stroke Date: 2021-02-18 Impact factor: 7.914