Amanda L Ngouajio1, Sarah M Drejet1, D Ryan Phillips1, Don-John Summerlin2, John P Dahl3. 1. Department of Otolaryngology Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. 2. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. 3. Department of Otolaryngology Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: jpdahl@iu.edu.
Abstract
IMPORTANCE: Mammary Analogue Secretory Carcinoma (MASC) is a newly characterized salivary gland carcinoma resembling secretory carcinoma of the breast. Prior to being described, MASC was most commonly misdiagnosed as Acinic Cell Carcinoma. Though MASC is predominantly an adult neoplasm, cases have been reported in the pediatric population. Reporting and summarizing of known cases is imperative to understand the prognosis and clinical behavior of MASC. OBJECTIVE: EVIDENCE REVIEW: Web of Science, Medline, EMBASE, and The Cochrane Library were searched for studies that included pediatric cases of MASC. Data on clinical presentation, diagnosis and management, and pathology were collected from all pediatric cases. FINDINGS: CONCLUSIONS AND RELEVANCE: Since the first case of MASC in the pediatric population was described in 2011, only 12 cases, including this one, have been described in the literature. With this paucity of information, much remains unknown regarding this new pathologic diagnosis. The collection of clinical outcomes data of children with MASC is needed to better understand the behavior of this malignancy as well as determine optimal treatment regimens.
IMPORTANCE: Mammary Analogue Secretory Carcinoma (MASC) is a newly characterized salivary gland carcinoma resembling secretory carcinoma of the breast. Prior to being described, MASC was most commonly misdiagnosed as Acinic Cell Carcinoma. Though MASC is predominantly an adult neoplasm, cases have been reported in the pediatric population. Reporting and summarizing of known cases is imperative to understand the prognosis and clinical behavior of MASC. OBJECTIVE: EVIDENCE REVIEW: Web of Science, Medline, EMBASE, and The Cochrane Library were searched for studies that included pediatric cases of MASC. Data on clinical presentation, diagnosis and management, and pathology were collected from all pediatric cases. FINDINGS: CONCLUSIONS AND RELEVANCE: Since the first case of MASC in the pediatric population was described in 2011, only 12 cases, including this one, have been described in the literature. With this paucity of information, much remains unknown regarding this new pathologic diagnosis. The collection of clinical outcomes data of children with MASC is needed to better understand the behavior of this malignancy as well as determine optimal treatment regimens.
Authors: Sami S Omar; Emily C Daugherty; Kakil I Rasul; Fahmi M Salih; Hawro T Hamza; Fahmi H Kakamad; Abdulwahid M Salih Journal: Int J Surg Case Rep Date: 2022-04-29
Authors: David Forner; Martin Bullock; Daniel Manders; Timothy Wallace; Christopher J Chin; Liane B Johnson; Matthew H Rigby; Jonathan R Trites; Mark S Taylor; Robert D Hart Journal: J Otolaryngol Head Neck Surg Date: 2018-11-16