Literature DB >> 28801069

HSC Niche Biology and HSC Expansion Ex Vivo.

Sachin Kumar1, Hartmut Geiger2.   

Abstract

Hematopoietic stem cell (HSC) transplantation can restore a new functional hematopoietic system in recipients in cases where the system of the recipient is not functional or for example is leukemic. However, the number of available donor HSCs is often too low for successful transplantation. Expansion of HSCs and thus HSC self-renewal ex vivo would greatly improve transplantation therapy in the clinic. In vivo, HSCs expand significantly in the niche, but establishing protocols that result in HSC expansion ex vivo remains challenging. In this review we discuss current knowledge of niche biology, the intrinsic regulators of HSC self-renewal in vivo, and introduce novel niche-informed strategies of HSC expansion ex vivo.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28801069      PMCID： PMC5600322          DOI： 10.1016/j.molmed.2017.07.003

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  178 in total

Review 1.  Making sense of hematopoietic stem cell niches.

Authors:  Philip E Boulais; Paul S Frenette
Journal:  Blood       Date:  2015-03-11       Impact factor: 22.113

2.  Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche.

Authors:  Ryohichi Sugimura; Xi C He; Aparna Venkatraman; Fumio Arai; Andrew Box; Craig Semerad; Jeffrey S Haug; Lai Peng; Xiao-Bo Zhong; Toshio Suda; Linheng Li
Journal:  Cell       Date:  2012-07-20       Impact factor: 41.582

3.  Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.

Authors:  Anthony E Boitano; Jian Wang; Russell Romeo; Laure C Bouchez; Albert E Parker; Sue E Sutton; John R Walker; Colin A Flaveny; Gary H Perdew; Michael S Denison; Peter G Schultz; Michael P Cooke
Journal:  Science       Date:  2010-08-05       Impact factor: 47.728

4.  The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

Authors:  Sushma Gurumurthy; Stephanie Z Xie; Brinda Alagesan; Judith Kim; Rushdia Z Yusuf; Borja Saez; Alexandros Tzatsos; Fatih Ozsolak; Patrice Milos; Francesco Ferrari; Peter J Park; Orian S Shirihai; David T Scadden; Nabeel Bardeesy
Journal:  Nature       Date:  2010-12-02       Impact factor: 49.962

5.  Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.

Authors:  Peggy Kirstetter; Kristina Anderson; Bo T Porse; Sten Eirik W Jacobsen; Claus Nerlov
Journal:  Nat Immunol       Date:  2006-09-03       Impact factor: 25.606

6.  In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1.

Authors:  Gerald de Haan; Ellen Weersing; Bert Dontje; Ronald van Os; Leonid V Bystrykh; Edo Vellenga; Geraldine Miller
Journal:  Dev Cell       Date:  2003-02       Impact factor: 12.270

7.  Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche.

Authors:  Junke Zheng; HoangDinh Huynh; Masato Umikawa; Robert Silvany; Cheng Cheng Zhang
Journal:  Blood       Date:  2010-10-19       Impact factor: 22.113

8.  A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche.

Authors:  Yoon-Young Jang; Saul J Sharkis
Journal:  Blood       Date:  2007-06-26       Impact factor: 22.113

9.  Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma without Cryopreservation.

Authors:  Khalid Ahmed Al-Anazi
Journal:  Bone Marrow Res       Date:  2012-05-28

10.  Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs.

Authors:  Hina Takano; Hideo Ema; Kazuhiro Sudo; Hiromitsu Nakauchi
Journal:  J Exp Med       Date:  2004-01-26       Impact factor: 14.307
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  31 in total

Review 1.  The hematopoietic stem cell diet.

Authors:  Adam C Wilkinson; Satoshi Yamazaki
Journal:  Int J Hematol       Date:  2018-03-31       Impact factor: 2.490

Review 2.  Stabilizing hematopoietic stem cells in vitro.

Authors:  Adam C Wilkinson; Hiromitsu Nakauchi
Journal:  Curr Opin Genet Dev       Date:  2020-06-20       Impact factor: 5.578

3.  Development of a novel and synthetic HematoMiR technology that broadly modulates quiescence of stem cells and enhances HSC expansion.

Authors:  Merve Uslu; Fatih Kocabaş
Journal:  Cell Mol Life Sci       Date:  2021-12-31       Impact factor: 9.261

Review 4.  Review old bone, new tricks.

Authors:  Livnat Barsky; Ifat Cohen-Erez; Igor Bado; Xiang H-F Zhang; Razi Vago
Journal:  Clin Exp Metastasis       Date:  2022-07-30       Impact factor: 4.510

Review 5.  In Vitro and In Vivo Modeling of Normal and Leukemic Bone Marrow Niches: Cellular Senescence Contribution to Leukemia Induction and Progression.

Authors:  Myriam Janeth Salazar-Terreros; Jean-Paul Vernot
Journal:  Int J Mol Sci       Date:  2022-07-01       Impact factor: 6.208

Review 6.  Haematopoietic stem cell self-renewal in vivo and ex vivo.

Authors:  Adam C Wilkinson; Kyomi J Igarashi; Hiromitsu Nakauchi
Journal:  Nat Rev Genet       Date:  2020-05-28       Impact factor: 53.242

7.  Differentiated Cells Derived from Hematopoietic Stem Cells and Their Applications in Translational Medicine.

Authors:  Sophia S Fernandes; Lalita S Limaye; Vaijayanti P Kale
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

8.  The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow.

Authors:  Dachuan Zhang; Xin Gao; Huihui Li; Daniel K Borger; Qiaozhi Wei; Eva Yang; Chunliang Xu; Sandra Pinho; Paul S Frenette
Journal:  Cell Stem Cell       Date:  2022-01-21       Impact factor: 24.633

9.  Pharmacological Inhibition of p38 MAPK Rejuvenates Bone Marrow Derived-Mesenchymal Stromal Cells and Boosts their Hematopoietic Stem Cell-Supportive Ability.

Authors:  Pallavi Budgude; Vaijayanti Kale; Anuradha Vaidya
Journal:  Stem Cell Rev Rep       Date:  2021-08-22       Impact factor: 5.739

10.  Base editing of haematopoietic stem cells rescues sickle cell disease in mice.

Authors:  Gregory A Newby; Jonathan S Yen; Kaitly J Woodard; Thiyagaraj Mayuranathan; Cicera R Lazzarotto; Yichao Li; Heather Sheppard-Tillman; Shaina N Porter; Yu Yao; Kalin Mayberry; Kelcee A Everette; Yoonjeong Jang; Christopher J Podracky; Elizabeth Thaman; Christophe Lechauve; Akshay Sharma; Jordana M Henderson; Michelle F Richter; Kevin T Zhao; Shannon M Miller; Tina Wang; Luke W Koblan; Anton P McCaffrey; John F Tisdale; Theodosia A Kalfa; Shondra M Pruett-Miller; Shengdar Q Tsai; Mitchell J Weiss; David R Liu
Journal:  Nature       Date:  2021-06-02       Impact factor: 49.962
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