Literature DB >> 28799649

Design of modular dual enzyme-responsive peptides.

Natalie Boehnke1, Heather D Maynard1.   

Abstract

Dual enzyme-responsive peptides were synthesized by masking the ɛ-amine of lysine with various enzyme substrates. Enzymatic cleavage of these sequences unmasked the ɛ-amine, allowing for further digestion by a second enzyme, which was monitored colorimetrically. This modular peptide design should provide substrates for a large combination of clinically relevant enzymes.
© 2017 Wiley Periodicals, Inc.

Entities:  

Keywords:  dual-enzyme; dual-enzyme assay; indirect enzyme detection; multi-enzyme; multi-enzyme assay; nitroanilide

Mesh：

Substances：

Year:  2017        PMID： 28799649      PMCID： PMC5963286          DOI： 10.1002/bip.23035

Source DB:  PubMed          Journal:  Biopolymers        ISSN： 0006-3525            Impact factor:   2.240


  32 in total

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