Dante De Paz1,2, Huang-Kai Kao3,4, Yenlin Huang4,5, Kai-Ping Chang6,7. 1. Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 2. Department of Head and Neck Surgery, San Pedro University, Chimbote, Peru. 3. Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 4. College of Medicine, Chang Gung University, Taoyuan, Taiwan. 5. Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 6. Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan. dr.kpchang@gmail.com. 7. College of Medicine, Chang Gung University, Taoyuan, Taiwan. dr.kpchang@gmail.com.
Abstract
PURPOSE OF REVIEW: Prognosis of advanced oral squamous cell carcinoma remains a challenge for clinicians despite progress in its diagnosis and treatment over the past decades. In this review, we assessed clinicopathological factors and potential biomarkers along with their prognostic relevance in an attempt to develop optimal treatment strategies for these patients. RECENT FINDINGS: In addition to several pathologic factors that have been proposed to improve prognostic stratification and treatment planning in the eighth edition of the American Joint Committee staging manual on cancer, we reviewed some other imaging and clinicopathological parameters demonstrated to be closely associated with patient prognosis, along with the biomarkers related to novel target or immune therapy. Evaluation of current literature regarding the prognostic stratification used in contemporary clinicopathological studies and progress in the development of targeted or immune therapy may help these patients benefit from tailored and personalized treatment and obtain better oncological results.
PURPOSE OF REVIEW: Prognosis of advanced oral squamous cell carcinoma remains a challenge for clinicians despite progress in its diagnosis and treatment over the past decades. In this review, we assessed clinicopathological factors and potential biomarkers along with their prognostic relevance in an attempt to develop optimal treatment strategies for these patients. RECENT FINDINGS: In addition to several pathologic factors that have been proposed to improve prognostic stratification and treatment planning in the eighth edition of the American Joint Committee staging manual on cancer, we reviewed some other imaging and clinicopathological parameters demonstrated to be closely associated with patient prognosis, along with the biomarkers related to novel target or immune therapy. Evaluation of current literature regarding the prognostic stratification used in contemporary clinicopathological studies and progress in the development of targeted or immune therapy may help these patients benefit from tailored and personalized treatment and obtain better oncological results.
Entities:
Keywords:
Head and neck; OSCC; Oral cancer; Oral cavity; Prognosis; Squamous cell carcinoma
Authors: Marlon C Rebelatto; Anita Midha; Amita Mistry; Constantine Sabalos; Nicole Schechter; Xia Li; Xiaoping Jin; Keith E Steele; Paul B Robbins; John A Blake-Haskins; Jill Walker Journal: Diagn Pathol Date: 2016-10-08 Impact factor: 2.644
Authors: Jacob G J Wihlidal; Keng Yeow Tay; S Danielle MacNeil; Anthony C Nichols; Kevin Fung; John H J Yoo; Adrian I Mendez Journal: Laryngoscope Investig Otolaryngol Date: 2022-08-16