Alfonsina D'Iorio1, Carmine Vitale2, Fausta Piscopo1, Chiara Baiano1, Anna Paola Falanga1, Katia Longo2, Marianna Amboni3, Paolo Barone4, Gabriella Santangelo5. 1. Neuropsychology and Memory Clinic, Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy. 2. Department of Motor Sciences and Wellness, University "Parthenope", Naples, Italy; Institute of Diagnosis and Care (IDC), Hermitage-Capodimonte, Naples, Italy. 3. Institute of Diagnosis and Care (IDC), Hermitage-Capodimonte, Naples, Italy; Department of Medicine, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Italy. 4. Department of Medicine, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Italy. 5. Neuropsychology and Memory Clinic, Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy; Institute of Diagnosis and Care (IDC), Hermitage-Capodimonte, Naples, Italy. Electronic address: gabriella.santangelo@unicampania.it.
Abstract
INTRODUCTION: Parkinson's disease (PD) is characterized by a wide spectrum of non-motor symptoms that may impact negatively on the activities of the patient's daily life and reduce Health-related quality of life (HRQoL). The present study explored the impact of specific non-motor symptoms on the HRQoL in PD. METHODS: Eighty-four outpatients underwent the Montreal Cognitive Assessment (MoCA) assessing global functioning and several questionnaires to assess depression, apathy, impulse control disorders (ICD), anxiety, anhedonia and functional impact of cognitive impairment. The perceived QoL was assessed by Parkinson's Disease Questionnaire (PDQ-8). The PD sample was divided into patients with high and low HRQoL around the median of PDQ-8 and compared on clinical features, cognitive and neuropsychiatric variables. A linear regression analysis, in which the global functioning, apathy, depression, anxiety, anhedonia, ICD and the functional autonomy scores were entered as independent variables and PDQ-8 score as dependent variable, was applied. RESULTS: Patients with lower HRQoL were more depressed, apathetic, anxious and showed more severe reduction of functional autonomy and global functioning than patients with high HRQoL. The regression analysis revealed that higher level of anxiety, executive apathy and more reduced functional autonomy were significantly associated with higher score on PDQ-8. CONCLUSIONS: The finding indicated that anxiety, apathy associated with impaired planning, attention and organization (i.e., executive apathy evaluated by the Dimensional Apathy Scale) and reduced functional autonomy contribute significantly to reduce the HRQoL in PD. Therefore, early identification and management of these neuropsychiatric symptoms should be relevant to preserve HRQoL in PD.
INTRODUCTION:Parkinson's disease (PD) is characterized by a wide spectrum of non-motor symptoms that may impact negatively on the activities of the patient's daily life and reduce Health-related quality of life (HRQoL). The present study explored the impact of specific non-motor symptoms on the HRQoL in PD. METHODS: Eighty-four outpatients underwent the Montreal Cognitive Assessment (MoCA) assessing global functioning and several questionnaires to assess depression, apathy, impulse control disorders (ICD), anxiety, anhedonia and functional impact of cognitive impairment. The perceived QoL was assessed by Parkinson's Disease Questionnaire (PDQ-8). The PD sample was divided into patients with high and low HRQoL around the median of PDQ-8 and compared on clinical features, cognitive and neuropsychiatric variables. A linear regression analysis, in which the global functioning, apathy, depression, anxiety, anhedonia, ICD and the functional autonomy scores were entered as independent variables and PDQ-8 score as dependent variable, was applied. RESULTS:Patients with lower HRQoL were more depressed, apathetic, anxious and showed more severe reduction of functional autonomy and global functioning than patients with high HRQoL. The regression analysis revealed that higher level of anxiety, executive apathy and more reduced functional autonomy were significantly associated with higher score on PDQ-8. CONCLUSIONS: The finding indicated that anxiety, apathy associated with impaired planning, attention and organization (i.e., executive apathy evaluated by the Dimensional Apathy Scale) and reduced functional autonomy contribute significantly to reduce the HRQoL in PD. Therefore, early identification and management of these neuropsychiatric symptoms should be relevant to preserve HRQoL in PD.
Authors: Jojo Y Y Kwok; Jackie C Y Kwan; M Auyeung; Vincent C T Mok; Claire K Y Lau; K C Choi; Helen Y L Chan Journal: JAMA Neurol Date: 2019-07-01 Impact factor: 18.302
Authors: Philippe Robert; Claire Albrengues; Roxane Fabre; Alexandre Derreumaux; Marie Pierre Pancrazi; Isabelle Luporsi; Bruno Dubois; Stéphane Epelbaum; Grégoire Mercier; Pierre Foulon; François Bremond; Valeria Manera Journal: Alzheimers Dement (N Y) Date: 2021-05-11
Authors: Mirnova E Ceïde; Alana Warhit; Emmeline I Ayers; Gary Kennedy; Joe Verghese Journal: J Gerontol B Psychol Sci Soc Sci Date: 2020-08-13 Impact factor: 4.077