Mitra Samareh Fekri1, Mehdi Torabi2, Sara Azizi Shoul3, Moghaddameh Mirzaee4. 1. Associate Professor of Pulmonology Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran. 2. Assistant Professor of Emergency Medicine, Department of Emergency Medicine, Kerman University of Medical Sciences, Clinical Research Center, Afzalipour Hospital, Kerman, Iran. Electronic address: me_torabi@kmu.ac.ir. 3. Department of Emergency Medicine, Kerman University of Medical Sciences, Kerman, Iran. 4. Department of Biostatistics and Epidemiology, School of Public Health, University of Medical Sciences, Kerman, Iran.
Abstract
BACKGROUND: Pulmonary hypertension (PH) is one of the most common complications of COPD (chronic obstructive pulmonary disease), but its severe form is uncommon. Various factors play an important role in the occurrence and severity of pulmonary hypertension in patients. METHODS: This cross-sectional study was performed on patients with COPD referred to an emergency department over a one-year period. The tests-including complete blood count (CBC) and arterial blood gas (ABG), pulmonary functional test (PFT) and echocardiography-were performed for all patients to measure mPAP (mean pulmonary artery pressure), ejection fraction (EF) and body mass index (BMI). The prevalence of severe pulmonary hypertension and its associated factors were investigated in these patients. RESULTS: A total of 1078 patients was included in the study, of whom 628 (58.3%) were male and 450 (41.7%) were female. The mean age of the patients undergoing the study was 70.1±12.2. A total of 136 (13.7%) of them had mPAP (mm Hg)≥40mm Hg as severe pulmonary hypertension. Following multivariable analysis by using the backward conditional method, it was shown that seven variables had a significant correlation with severe PH. CONCLUSIONS: The results showed that there is an independent correlation between hypoxia, hypopnea and compensatory metabolic alkalosis, polycythemia, left ventricular dysfunction, emaciation, and cachectic with severe pulmonary hypertension. The prevalence of severe PH in these patients was 13.7%.
BACKGROUND:Pulmonary hypertension (PH) is one of the most common complications of COPD (chronic obstructive pulmonary disease), but its severe form is uncommon. Various factors play an important role in the occurrence and severity of pulmonary hypertension in patients. METHODS: This cross-sectional study was performed on patients with COPD referred to an emergency department over a one-year period. The tests-including complete blood count (CBC) and arterial blood gas (ABG), pulmonary functional test (PFT) and echocardiography-were performed for all patients to measure mPAP (mean pulmonary artery pressure), ejection fraction (EF) and body mass index (BMI). The prevalence of severe pulmonary hypertension and its associated factors were investigated in these patients. RESULTS: A total of 1078 patients was included in the study, of whom 628 (58.3%) were male and 450 (41.7%) were female. The mean age of the patients undergoing the study was 70.1±12.2. A total of 136 (13.7%) of them had mPAP (mm Hg)≥40mm Hg as severe pulmonary hypertension. Following multivariable analysis by using the backward conditional method, it was shown that seven variables had a significant correlation with severe PH. CONCLUSIONS: The results showed that there is an independent correlation between hypoxia, hypopnea and compensatory metabolic alkalosis, polycythemia, left ventricular dysfunction, emaciation, and cachectic with severe pulmonary hypertension. The prevalence of severe PH in these patients was 13.7%.
Authors: Priyanka T Bhattacharya; Asif M Abdul Hameed; Shubhadeep T Bhattacharya; Julio A Chirinos; Wei-Ting Hwang; Edo Y Birati; Jonathan N Menachem; Saurav Chatterjee; Jay S Giri; Steven M Kawut; Stephen E Kimmel; Jeremy A Mazurek Journal: Pulm Circ Date: 2020-11-23 Impact factor: 3.017
Authors: Michael H Cho; Brian D Hobbs; Jingzhou Zhang; Dawn L DeMeo; Edwin K Silverman; Barry J Make; R Chad Wade; J Michael Wells Journal: BMC Pulm Med Date: 2021-07-14 Impact factor: 3.320