Literature DB >> 28796205

Therapeutics: Click and discover.

George S Vassiliou1, Shankar Balasubramanian2.   

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Year:  2017        PMID: 28796205     DOI: 10.1038/548162a

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


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  10 in total

1.  Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

Authors:  Hartmuth C. Kolb; M. G. Finn; K. Barry Sharpless
Journal:  Angew Chem Int Ed Engl       Date:  2001-06-01       Impact factor: 15.336

Review 2.  Unravelling the genomic targets of small molecules using high-throughput sequencing.

Authors:  Raphaël Rodriguez; Kyle M Miller
Journal:  Nat Rev Genet       Date:  2014-10-14       Impact factor: 53.242

3.  Identifying the proteins to which small-molecule probes and drugs bind in cells.

Authors:  Shao-En Ong; Monica Schenone; Adam A Margolin; Xiaoyu Li; Kathy Do; Mary K Doud; D R Mani; Letian Kuai; Xiang Wang; John L Wood; Nicola J Tolliday; Angela N Koehler; Lisa A Marcaurelle; Todd R Golub; Robert J Gould; Stuart L Schreiber; Steven A Carr
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-02       Impact factor: 11.205

Review 4.  An analysis of the attrition of drug candidates from four major pharmaceutical companies.

Authors:  Michael J Waring; John Arrowsmith; Andrew R Leach; Paul D Leeson; Sam Mandrell; Robert M Owen; Garry Pairaudeau; William D Pennie; Stephen D Pickett; Jibo Wang; Owen Wallace; Alex Weir
Journal:  Nat Rev Drug Discov       Date:  2015-06-19       Impact factor: 84.694

5.  Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.

Authors:  Melissa L Blackman; Maksim Royzen; Joseph M Fox
Journal:  J Am Chem Soc       Date:  2008-09-18       Impact factor: 15.419

6.  Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition.

Authors:  Anna E Speers; Gregory C Adam; Benjamin F Cravatt
Journal:  J Am Chem Soc       Date:  2003-04-23       Impact factor: 15.419

7.  BET inhibitor resistance emerges from leukaemia stem cells.

Authors:  Chun Yew Fong; Omer Gilan; Enid Y N Lam; Alan F Rubin; Sarah Ftouni; Dean Tyler; Kym Stanley; Devbarna Sinha; Paul Yeh; Jessica Morison; George Giotopoulos; Dave Lugo; Philip Jeffrey; Stanley Chun-Wei Lee; Christopher Carpenter; Richard Gregory; Robert G Ramsay; Steven W Lane; Omar Abdel-Wahab; Tony Kouzarides; Ricky W Johnstone; Sarah-Jane Dawson; Brian J P Huntly; Rab K Prinjha; Anthony T Papenfuss; Mark A Dawson
Journal:  Nature       Date:  2015-09-14       Impact factor: 49.962

8.  Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

Authors:  Mark A Dawson; Rab K Prinjha; Antje Dittmann; George Giotopoulos; Marcus Bantscheff; Wai-In Chan; Samuel C Robson; Chun-wa Chung; Carsten Hopf; Mikhail M Savitski; Carola Huthmacher; Emma Gudgin; Dave Lugo; Soren Beinke; Trevor D Chapman; Emma J Roberts; Peter E Soden; Kurt R Auger; Olivier Mirguet; Konstanze Doehner; Ruud Delwel; Alan K Burnett; Phillip Jeffrey; Gerard Drewes; Kevin Lee; Brian J P Huntly; Tony Kouzarides
Journal:  Nature       Date:  2011-10-02       Impact factor: 49.962

9.  Click chemistry enables preclinical evaluation of targeted epigenetic therapies.

Authors:  Dean S Tyler; Johanna Vappiani; Tatiana Cañeque; Enid Y N Lam; Aoife Ward; Omer Gilan; Yih-Chih Chan; Antje Hienzsch; Anna Rutkowska; Thilo Werner; Anne J Wagner; Dave Lugo; Richard Gregory; Cesar Ramirez Molina; Neil Garton; Christopher R Wellaway; Susan Jackson; Laura MacPherson; Margarida Figueiredo; Sabine Stolzenburg; Charles C Bell; Colin House; Sarah-Jane Dawson; Edwin D Hawkins; Gerard Drewes; Rab K Prinjha; Raphaël Rodriguez; Paola Grandi; Mark A Dawson
Journal:  Science       Date:  2017-06-15       Impact factor: 47.728

10.  Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.

Authors:  Raphaël Rodriguez; Kyle M Miller; Josep V Forment; Charles R Bradshaw; Mehran Nikan; Sébastien Britton; Tobias Oelschlaegel; Blerta Xhemalce; Shankar Balasubramanian; Stephen P Jackson
Journal:  Nat Chem Biol       Date:  2012-02-05       Impact factor: 15.040

  10 in total

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