Literature DB >> 28793795

Lipid Droplet Biogenesis.

Tobias C Walther1,2,3,4, Jeeyun Chung1,2, Robert V Farese1,2,3.   

Abstract

Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo, converting cells to emulsions with LDs constituting the dispersed oil phase in the aqueous cytoplasm. Here we review our current view of LD biogenesis. We present a model of LD formation from the ER in distinct steps and highlight the biology of proteins that govern this biophysical process. Areas of incomplete knowledge are identified, as are connections with physiology and diseases linked to alterations in LD biology.

Entities:  

Keywords:  biogenesis; endoplasmic reticulum; lipid droplets; neutral lipids; seipin; sterol esters; triacylglycerol; triglycerides

Mesh：

Substances：

Year:  2017        PMID： 28793795      PMCID： PMC6986389          DOI： 10.1146/annurev-cellbio-100616-060608

Source DB:  PubMed          Journal:  Annu Rev Cell Dev Biol        ISSN： 1081-0706            Impact factor:   13.827


  151 in total

1.  The enzymatic synthesis of triglycerides.

Authors:  S B WEISS; E P KENNEDY; J Y KIYASU
Journal:  J Biol Chem       Date:  1960-01       Impact factor: 5.157

2.  A Model for Shaping Membrane Sheets by Protein Scaffolds.

Authors:  Yonatan Schweitzer; Tom Shemesh; Michael M Kozlov
Journal:  Biophys J       Date:  2015-08-04       Impact factor: 4.033

3.  The lipid-droplet proteome reveals that droplets are a protein-storage depot.

Authors:  Silvia Cermelli; Yi Guo; Steven P Gross; Michael A Welte
Journal:  Curr Biol       Date:  2006-09-19       Impact factor: 10.834

4.  Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption.

Authors:  Dong Cheng; Thomas C Nelson; Jian Chen; Stephen G Walker; Judith Wardwell-Swanson; Rupalie Meegalla; Rebecca Taub; Jeffrey T Billheimer; Michael Ramaker; John N Feder
Journal:  J Biol Chem       Date:  2003-03-03       Impact factor: 5.157

5.  Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes.

Authors:  Dawn L Brasaemle; Georgia Dolios; Lawrence Shapiro; Rong Wang
Journal:  J Biol Chem       Date:  2004-08-27       Impact factor: 5.157

6.  A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum.

Authors:  Hidde L Ploegh
Journal:  Nature       Date:  2007-07-26       Impact factor: 49.962

7.  A class of membrane proteins shaping the tubular endoplasmic reticulum.

Authors:  Gia K Voeltz; William A Prinz; Yoko Shibata; Julia M Rist; Tom A Rapoport
Journal:  Cell       Date:  2006-02-10       Impact factor: 41.582

8.  Subcellular location and topography of rat hepatic monoacylglycerol acyltransferase activity.

Authors:  R A Coleman; E B Haynes
Journal:  Biochim Biophys Acta       Date:  1985-04-25

Review 9.  The biophysics and cell biology of lipid droplets.

Authors:  Abdou Rachid Thiam; Robert V Farese; Tobias C Walther
Journal:  Nat Rev Mol Cell Biol       Date:  2013-11-13       Impact factor: 94.444

Review 10.  Balancing the fat: lipid droplets and human disease.

Authors:  Natalie Krahmer; Robert V Farese; Tobias C Walther
Journal:  EMBO Mol Med       Date:  2013-06-06       Impact factor: 12.137
View more
  171 in total

1.  The Puzzling Conservation and Diversification of Lipid Droplets from Bacteria to Eukaryotes.

Authors:  Josselin Lupette; Eric Maréchal
Journal:  Results Probl Cell Differ       Date:  2020

Review 2.  Parkinson's disease: proteinopathy or lipidopathy?

Authors:  Saranna Fanning; Dennis Selkoe; Ulf Dettmer
Journal:  NPJ Parkinsons Dis       Date:  2020-01-03

Review 3.  The assembly of lipid droplets and their roles in challenged cells.

Authors:  W Mike Henne; Michael L Reese; Joel M Goodman
Journal:  EMBO J       Date:  2018-05-22       Impact factor: 11.598

4.  Electron Tomography Revels that Milk Lipids Originate from Endoplasmic Reticulum Domains with Novel Structural Features.

Authors:  Mark S Ladinsky; Gonzalo A Mardones; David J Orlicky; Kathryn E Howell; James L McManaman
Journal:  J Mammary Gland Biol Neoplasia       Date:  2019-11-10       Impact factor: 2.673

5.  Mitochondrial FgEch1 is responsible for conidiation and full virulence in Fusarium graminearum.

Authors:  Lin Tang; Xiaoyang Yu; Li Zhang; Liyuan Zhang; Lei Chen; Shenshen Zou; Yuancun Liang; Jinfeng Yu; Hansong Dong
Journal:  Curr Genet       Date:  2019-08-28       Impact factor: 3.886

6.  Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting.

Authors:  Maria-Jesus Olarte; Siyoung Kim; Morris E Sharp; Jessica M J Swanson; Robert V Farese; Tobias C Walther
Journal:  Dev Cell       Date:  2020-07-29       Impact factor: 12.270

Review 7.  Converging cellular themes for the hereditary spastic paraplegias.

Authors:  Craig Blackstone
Journal:  Curr Opin Neurobiol       Date:  2018-05-10       Impact factor: 6.627

Review 8.  Lipid Droplets as Organelles.

Authors:  Sarah Cohen
Journal:  Int Rev Cell Mol Biol       Date:  2018-02-12       Impact factor: 6.813

9.  The Surface and Hydration Properties of Lipid Droplets.

Authors:  Siyoung Kim; Jessica M J Swanson
Journal:  Biophys J       Date:  2020-10-14       Impact factor: 4.033

10.  A Proteomic Map to Navigate Subcellular Reorganization in Fatty Liver Disease.

Authors:  Zhipeng Li; James A Olzmann
Journal:  Dev Cell       Date:  2018-10-22       Impact factor: 12.270
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.