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Literature DB >> 2879376

Age-related peptide production by human thyroid C cells. An immunohistochemical study.

C H Kendall, C E Homer, A E Bishop, J M Polak.

Abstract

C cells of thyroid are known to express a variety of products beside calcitonin. These include the peptides PDN21 (katacalcin), calcitonin-gene related peptide (CGRP), bombesin and somatostatin. The expression of these products has been investigated by immunohistochemistry of thyroid tissue in six age ranges from fetal to late adult life. PDN 21 was found to have co-expression with calcitonin. CGRP and bombesin both demonstrated an age-related increase in numbers and intensity of cells stained. Somatostatin immunoreactivity was limited to small numbers of cells.

Entities: Gene Species

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Year: 1986 PMID： 2879376 DOI： 10.1007/bf00713511

Source DB: PubMed Journal: Virchows Arch A Pathol Anat Histopathol ISSN： 0174-7398

22 in total

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Authors: L I Larsson; L M Jørgensen
Journal: Cell Tissue Res Date: 1978-11-09 Impact factor: 5.249

2. Single cellular origin of somatostatin and calcitonin in the rat thyroid gland.

Authors: S Van Noorden; J M Polak; A G Pearse
Journal: Histochemistry Date: 1977-08-22

3. Chromogranin: a newly recognized marker for endocrine cells of the human gastrointestinal tract.

Authors: P Facer; A E Bishop; R V Lloyd; B S Wilson; R J Hennessy; J M Polak
Journal: Gastroenterology Date: 1985-12 Impact factor: 22.682

4. Partial nucleotide sequence of human calcitonin precursor mRNA identifies flanking cryptic peptides.

Authors: R K Craig; L Hall; M R Edbrooke; J Allison; I MacIntyre
Journal: Nature Date: 1982-01-28 Impact factor: 49.962

5. Transformation of catecholaminergic precursors into glucagon (A) cells in mouse embryonic pancreas.

Authors: G Teitelman; T H Joh; D J Reis
Journal: Proc Natl Acad Sci U S A Date: 1981-08 Impact factor: 11.205

6. Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.

Authors: B D Nelkin; K I Rosenfeld; A de Bustros; S S Leong; B A Roos; S B Baylin
Journal: Biochem Biophys Res Commun Date: 1984-09-17 Impact factor: 3.575

7. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.

Authors: S G Amara; V Jonas; M G Rosenfeld; E S Ong; R M Evans
Journal: Nature Date: 1982-07-15 Impact factor: 49.962

8. Salmon and human calcitonin-like peptides coexist in the human thyroid and brain.

Authors: J A Fischer; P H Tobler; H Henke; F A Tschopp
Journal: J Clin Endocrinol Metab Date: 1983-12 Impact factor: 5.958

9. Immunocytochemical localisation of katacalcin, a calcium-lowering hormone cleaved from the human calcitonin precursor.

Authors: A Ali-Rachedi; I M Varndell; P Facer; C J Hillyard; R K Craig; I MacIntyre; J M Polak
Journal: J Clin Endocrinol Metab Date: 1983-09 Impact factor: 5.958

10. Immunoreactive human chromogranin A in diverse polypeptide hormone producing human tumors and normal endocrine tissues.

Authors: D T O'Connor; D Burton; L J Deftos
Journal: J Clin Endocrinol Metab Date: 1983-11 Impact factor: 5.958

3 in total