Literature DB >> 28791568

Synthesis and biological evaluation of glycosides containing triazene-chalcones.

Qiang Lei1,2, Saiyang Zhang3, Manli Liu1, Jia Li1, Xi Zhang1, Yue Long4.   

Abstract

By combining triazenes with chalcones, we designed and synthesized 12 novel glycosides. The antiproliferative activity of all products was screened using an MTT assay against MGC803 cells and PC-3 cells. Compound [Formula: see text] displayed more potent antiproliferative activity than dacarbazine. Furthermore, we explored the preliminary structure activity relationship of all target compounds. The derivatives in this work might serve as bioactive fragments and lead compounds for developing more potent cytotoxic agents.

Entities:  

Keywords:  Antiproliferative activity; Chalcone; Glycosides; Synthesis; Triazene

Mesh：

Substances：

Year:  2017        PMID： 28791568     DOI： 10.1007/s11030-017-9768-1

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  21 in total

1.  Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.

Authors:  W P Roos; L F Z Batista; S C Naumann; W Wick; M Weller; C F M Menck; B Kaina
Journal:  Oncogene       Date:  2006-07-03       Impact factor: 9.867

2.  Synthesis of novel pyrazolic analogues of chalcones and their 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents.

Authors:  Braulio Insuasty; Alexis Tigreros; Fabián Orozco; Jairo Quiroga; Rodrigo Abonía; Manuel Nogueras; Adolfo Sanchez; Justo Cobo
Journal:  Bioorg Med Chem       Date:  2010-06-09       Impact factor: 3.641

3.  Palladium-nanoparticle-catalyzed 1,7-palladium migration involving C-H activation, followed by intramolecular amination: regioselective synthesis of N1-arylbenzotriazoles and an evaluation of their inhibitory activity toward indoleamine 2,3-dioxygenase.

Authors:  Koji Takagi; Mohammad Al-Amin; Naoyuki Hoshiya; Johan Wouters; Hiroshi Sugimoto; Yoshitsugu Shiro; Hayato Fukuda; Satoshi Shuto; Mitsuhiro Arisawa
Journal:  J Org Chem       Date:  2014-06-24       Impact factor: 4.354

4.  Synthesis of 4'-hydroxy-3'-piperidinomethylchalcone derivatives and their cytotoxicity against PC-3 cell lines.

Authors:  Halise I Gul; Kadir O Yerdelen; Mustafa Gul; Umashankar Das; Bulbul Pandit; Pui-Kai Li; Hasan Secen; Fikrettin Sahin
Journal:  Arch Pharm (Weinheim)       Date:  2007-04       Impact factor: 3.751

5.  Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.

Authors:  Wynand Roos; Manuela Baumgartner; Bernd Kaina
Journal:  Oncogene       Date:  2004-01-15       Impact factor: 9.867

6.  Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones.

Authors:  Naveen Kumar Konduru; Sunita Dey; Mohammad Sajid; Mohammad Owais; Naseem Ahmed
Journal:  Eur J Med Chem       Date:  2012-09-10       Impact factor: 6.514

7.  Synthesis, cytotoxic and combined cDDP activity of new stable curcumin derivatives.

Authors:  Erika Ferrari; Sandra Lazzari; Gaetano Marverti; Francesca Pignedoli; Ferdinando Spagnolo; Monica Saladini
Journal:  Bioorg Med Chem       Date:  2009-03-14       Impact factor: 3.641

8.  Discovery of 2'-hydroxychalcones as autophagy inducer in A549 lung cancer cells.

Authors:  Fang-Wu Wang; Sheng-Qing Wang; Bao-Xiang Zhao; Jun-Ying Miao
Journal:  Org Biomol Chem       Date:  2014-05-21       Impact factor: 3.876

9.  Novel role of triazenes in haematological malignancies: pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia.

Authors:  Patrizia Caporaso; Mario Turriziani; Adriano Venditti; Francesco Marchesi; Francesco Buccisano; Maria Cristina Tirindelli; Ester Alvino; Alberto Garbin; Grazia Tortorelli; Laura Toppo; Enzo Bonmassar; Stefania D'Atri; Sergio Amadori
Journal:  DNA Repair (Amst)       Date:  2007-05-17

Review 10.  Biological roles of oligosaccharides: all of the theories are correct.

Authors:  A Varki
Journal:  Glycobiology       Date:  1993-04       Impact factor: 4.313
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