Literature DB >> 24695783

Discovery of 2'-hydroxychalcones as autophagy inducer in A549 lung cancer cells.

Fang-Wu Wang1, Sheng-Qing Wang, Bao-Xiang Zhao, Jun-Ying Miao.   

Abstract

A series of 2'-hydroxychalcone derivatives was synthesized and the effects of all the compounds on growth of A549 lung cancer cell were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound possessed the highest growth inhibitory effect and induced autophagy of A549 lung cancer cells.

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Year:  2014        PMID： 24695783     DOI： 10.1039/c3ob42429d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  Synthesis and biological evaluation of glycosides containing triazene-chalcones.

Authors:  Qiang Lei; Saiyang Zhang; Manli Liu; Jia Li; Xi Zhang; Yue Long
Journal:  Mol Divers       Date:  2017-08-08       Impact factor: 2.943

2.  2'-Hydroxychalcones as an alternative treatment for trichomoniasis in association with metronidazole.

Authors:  Raquel Nascimento das Neves; Ângela Sena-Lopes; Mirna Samara Dié Alves; Bárbara da Rocha Fonseca; Caroline Carapina da Silva; Angela Maria Casaril; Lucielli Savegnago; Claudio Martin Pereira de Pereira; Daniela Fernandes Ramos; Sibele Borsuk
Journal:  Parasitol Res       Date:  2019-12-18       Impact factor: 2.289

3.  A small molecule targeting glutathione activates Nrf2 and inhibits cancer cell growth through promoting Keap-1 S-glutathionylation and inducing apoptosis.

Authors:  LiHong Wang; GuoJing Qu; YuanDi Gao; Le Su; Qing Ye; Fan Jiang; BaoXiang Zhao; JunYing Miao
Journal:  RSC Adv       Date:  2018-01-03       Impact factor: 4.036

4.  Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition.

Authors:  Yi-Ming Ma; Yan-Min Peng; Qiong-Hua Zhu; An-Hui Gao; Bo Chao; Qiao-Jun He; Jia Li; You-Hong Hu; Yu-Bo Zhou
Journal:  Acta Pharmacol Sin       Date:  2016-06-06       Impact factor: 6.150

5.  Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo.

Authors:  Xuan Zhao; WenLiang Dong; YuanDi Gao; Dong-Shoo Shin; Qing Ye; Le Su; Fan Jiang; BaoXiang Zhao; JunYing Miao
Journal:  Sci Rep       Date:  2017-06-20       Impact factor: 4.379

6.  Identification of novel small molecule Beclin 1 mimetics activating autophagy.

Authors:  Jia Yu; Lan Lan; Seth J Lewin; Steven A Rogers; Anuradha Roy; Xiaoqing Wu; Philip Gao; John Karanicolas; Jeffrey Aubé; Baiwang Sun; Liang Xu
Journal:  Oncotarget       Date:  2017-05-18
  6 in total

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