Literature DB >> 2879017

The affinity of some selective muscarinic receptor antagonists for the muscarinic receptor mediating endothelial-dependent relaxation of the rabbit and rat thoracic aorta.

L K Choo, E Malta, F Mitchelson.   

Abstract

The pKB values determined for pirenzepine, 4-DAMP, secoverine and gallamine against acetylcholine-mediated relaxant effects in rabbit aorta indicate that this muscarinic receptor closely resembles that which mediates contraction of non-vascular smooth muscle. The results of the present study argue against the presence of a novel type of muscarinic receptor mediating endothelium-dependent relaxation.

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Year:  1986        PMID： 2879017     DOI： 10.1111/j.2042-7158.1986.tb04507.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  6 in total

1.  Radioligand binding to muscarinic receptors of bovine aortic endothelial cells.

Authors:  F Brunner; W R Kukovetz
Journal:  Br J Pharmacol       Date:  1991-02       Impact factor: 8.739

2.  Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo.

Authors:  J Wess; P Angeli; C Melchiorre; U Moser; E Mutschler; G Lambrecht
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-09       Impact factor: 3.000

3.  Inhibition of endothelium-dependent vasorelaxation by arginine analogues: a pharmacological analysis of agonist and tissue dependence.

Authors:  G R Martin; M L Bolofo; H Giles
Journal:  Br J Pharmacol       Date:  1992-03       Impact factor: 8.739

4.  The interaction of parafluorohexahydrosiladiphenidol at muscarinic receptors in vitro.

Authors:  R M Eglen; A D Michel; W W Montgomery; E A Kunysz; C A Machado; R L Whiting
Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739

5.  Release of endothelium-derived hyperpolarizing factor (EDHF) by M3 receptor stimulation in guinea-pig coronary artery.

Authors:  A K Hammarström; H C Parkington; H A Coleman
Journal:  Br J Pharmacol       Date:  1995-07       Impact factor: 8.739

6.  The interaction of methoctramine and himbacine at atrial, smooth muscle and endothelial muscarinic receptors in vitro.

Authors:  R M Eglen; W W Montgomery; I A Dainty; L K Dubuque; R L Whiting
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739
  6 in total

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