| Literature DB >> 28786073 |
Mao-Sheng Fang1, Xing Li2, Hong Qian1, Kuan Zeng1,2, Meng Ye1, Yong-Jie Zhou1, Hui Li1, Xiao-Chuan Wang3,4, Yi Li5.
Abstract
This study was to determine the protective effect of ω-3 polyunsaturated fatty acids (ω-3PUFAs) on MK-801-induced cognitive impairment in schizophrenia (SZ) rats and the underlying mechanism. A rat model of schizophrenia was induced by MK-801. The cognitive function of rats was assessed using a Morris water maze. The number of hippocampal neurons was measured by Nissl staining. The expression of CREB, p-CREB, BDNF, TrkB, p-TrkB, AKT, p-AKT, ERK, and p-ERK in the hippocampus of rats was detected by Western blotting. The results showed that ω-3PUFAs attenuated MK-801-induced cognitive impairment and hippocampal neurons loss, reversed the injury of the CREB/BDNF/TrkB pathway induced by MK-801, and antagonized MK-801-induced down-regulation of p-AKT and p-ERK in the hippocampus of rats. In conclusion, ω-3PUFAs enhances the CREB/BDNF/TrkB pathway by activating ERK and AKT, thereby increasing the synaptic plasticity and decreasing neuron loss, and antagonizing MK-801-induced cognitive impairment in schizophrenic rats.Entities:
Keywords: CREB/BDNF/TrkB pathway; MK-801; cognition impairment; schizophrenia; ω-3 polyunsaturated fatty acids
Mesh：
Substances：
Year: 2017 PMID： 28786073 DOI： 10.1007/s11596-017-1762-4
Source DB: PubMed Journal: J Huazhong Univ Sci Technolog Med Sci ISSN： 1672-0733