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Literature DB >> 2878380

Postmortem changes in the enzymes of GABA and glutamate metabolism in the cerebellum and forebrain of newborn and adult rats.

Abstract

Postmortem changes in the activity of GDH, GAD, GABA-T, and GS in the adult forebrain and cerebellum and in the forebrain of newborns have been investigated. The activities of GDH, GAD, and GS were stable till 12 hr after death in both adult and young brain regions studied. The activity of GABA-T was stable till 30 min postmortem, but declined progressively thereafter in both regions in adult, as well as in young forebrain.

Entities: Chemical Disease Gene Species

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Year: 1986 PMID： 2878380 DOI： 10.1007/bf00966226

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

12 in total

1. Stability of enzymes in post-mortem rat brain.

Authors: S Fahn; L J Côté
Journal: J Neurochem Date: 1976-05 Impact factor: 5.372

2. Regional gamma-aminobutyric acid levels in rat brain determined after microwave fixation.

Authors: G J Balcom; R H Lenox; J L Meyerhoff
Journal: J Neurochem Date: 1975-04 Impact factor: 5.372

3. The effects of some newer anaesthetics on the in vitro activity of glutamate decarboxylase and GABA transaminase in crude brain extracts and on the levels of amino acids in vivo.

Authors: D J Dye; P V Taberner
Journal: J Neurochem Date: 1975-05 Impact factor: 5.372

8. Post-mortem stability of dopamine, glutamate decarboxylase and choline acetyltransferase in the mouse brain under conditions simulating the handling of human autopsy material.

Authors: E G Spokes; D J Koch
Journal: J Neurochem Date: 1978-07 Impact factor: 5.372

Postmortem changes in the enzymes of GABA and glutamate metabolism in the cerebellum and forebrain of newborn and adult rats.

1. Stability of enzymes in post-mortem rat brain.

2. Regional gamma-aminobutyric acid levels in rat brain determined after microwave fixation.

3. The effects of some newer anaesthetics on the in vitro activity of glutamate decarboxylase and GABA transaminase in crude brain extracts and on the levels of amino acids in vivo.

4. Some properties of L-glutamic decarboxylase in mouse brain.

5. Preparation and properties of mitochondria derived from synaptosomes.

6. Effects of undernutrition and protein deficiency on glutamate dehydrogenase and decarboxylase in rat brain.

7. Brain glutamate decarboxylase: changes in the developing rat brain.

8. Post-mortem stability of dopamine, glutamate decarboxylase and choline acetyltransferase in the mouse brain under conditions simulating the handling of human autopsy material.

9. Assay for glutamine synthetase activity.

10. Metabolic compartmentation of glutamate associated with the formation of gamma-aminobutyrate.

1. Cerebellar glutamate metabolizing enzymes in spinocerebellar ataxia type I.