| Literature DB >> 28783677 |
M Anthony Moody1,2,3, Isabela Pedroza-Pacheco4, Nathan A Vandergrift5,6, Cecilia Chui4, Krissey E Lloyd5, Robert Parks5, Kelly A Soderberg5, Ane T Ogbe4, Myron S Cohen7, Hua-Xin Liao5,6, Feng Gao5,6, Andrew J McMichael4, David C Montefiori8, Laurent Verkoczy5,6,9, Garnett Kelsoe5,2, Jinghe Huang10, Patrick R Shea11, Mark Connors10, Persephone Borrow12, Barton F Haynes1,2,6.
Abstract
Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1-infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1-infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1-infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4+ T cells, a higher frequency of circulating memory T follicular helper CD4+ cells, and a higher T regulatory cell level of programmed cell death-1 expression compared with HIV-1-infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1-infected individuals.Entities:
Year: 2016 PMID： 28783677 PMCID： PMC5589960 DOI： 10.1126/sciimmunol.aag0851
Source DB: PubMed Journal: Sci Immunol ISSN： 2470-9468