Hong-Bing Yao1, Senwei Tang2, Xiaotian Yao2, Hui-Yuan Yeh3, Wanhu Zhang4, Zhiyan Xie4, Qiajun Du5, Liying Ma1, Shuoyun Wei1, Xue Gong1, Zilong Zhang1, Quanfang Li1, Bingying Xu6, Hu-Qin Zhang7, Gang Chen2, Chuan-Chao Wang8,9,10. 1. Key Laboratory of Evidence Science of Gansu Province, Gansu Institute of Political Science and Law, Lanzhou, 730070, China. 2. WeGene, Shenzhen, 518040, China. 3. School of Humanities and School of Medicine, Nanyang Technological University, 639798, Singapore. 4. People's Hospital of Gaotai, Gaotai, Gansu Province, 734300, China. 5. Lanzhou University Second Hospital Clinical Laboratory, Lanzhou, Gansu Province, 730000, China. 6. School of Forensic Medicine, Kunming Medical University, Kunming, 650500, China. 7. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China. 8. Department of Anthropology and Ethnology, Xiamen University, Xiamen, 361005, China. 9. Department of Archaeogenetics and Eurasia3angle research group, Max Planck Institute for the Science of Human History, Jena, D-07745, Germany. 10. Department of Genetics, Harvard Medical School, Boston, Massachusetts, 02115.
Abstract
OBJECTIVES: The Tibetan-Yi Corridor located on the eastern edge of Tibetan Plateau is suggested to be the key region for the origin and diversification of Tibeto-Burman speaking populations and the main route of the peopling of the Plateau. However, the genetic history of the populations in the Corridor is far from clear due to limited sampling in the northern part of the Corridor. MATERIALS AND METHODS: We collected blood samples from 10 Tibetan and 10 Han Chinese individuals from Gansu province and genotyped about 600,000 genome-wide single nucleotide polymorphisms (SNPs). RESULTS: Our data revealed that the populations in the Corridor are all admixed on a genetic cline of deriving ancestry from Tibetans on the Plateau and surrounding lowland East Asians. The Tibetan and Han Chinese groups in the north of the Plateau show significant evidence of low-level West Eurasian admixture that could be probably traced back to 600∼900 years ago. DISCUSSION: We conclude that there have been huge population migrations from surrounding lowland onto the Tibetan Plateau via the Tibetan-Yi Corridor since the initial formation of Tibetans probably in Neolithic Time, which leads to the current genetic structure of Tibeto-Burman speaking populations.
OBJECTIVES: The Tibetan-Yi Corridor located on the eastern edge of Tibetan Plateau is suggested to be the key region for the origin and diversification of Tibeto-Burman speaking populations and the main route of the peopling of the Plateau. However, the genetic history of the populations in the Corridor is far from clear due to limited sampling in the northern part of the Corridor. MATERIALS AND METHODS: We collected blood samples from 10 Tibetan and 10 Han Chinese individuals from Gansu province and genotyped about 600,000 genome-wide single nucleotide polymorphisms (SNPs). RESULTS: Our data revealed that the populations in the Corridor are all admixed on a genetic cline of deriving ancestry from Tibetans on the Plateau and surrounding lowland East Asians. The Tibetan and Han Chinese groups in the north of the Plateau show significant evidence of low-level West Eurasian admixture that could be probably traced back to 600∼900 years ago. DISCUSSION: We conclude that there have been huge population migrations from surrounding lowland onto the Tibetan Plateau via the Tibetan-Yi Corridor since the initial formation of Tibetans probably in Neolithic Time, which leads to the current genetic structure of Tibeto-Burman speaking populations.