Aneesha Acharya1, Yuki Chan2, Supriya Kheur3, Li Jian Jin4, Rory M Watt5, Nikos Mattheos6. 1. Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative Region; Dr. D.Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, India. Electronic address: aneesha.a2@gmail.com. 2. Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: yukicyk@hku.hk. 3. Dr. D.Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, India. Electronic address: drskheur@gmail.com. 4. Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: ljjin@hku.hk. 5. Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: rmwatt@hku.hk. 6. Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: nikos@mattheos.net.
Abstract
OBJECTIVE: The advent of high-throughput sequencing and 'omic' technologies is facilitating an 'open-ended' understanding of the human microbial community and its interplay with health. This commentary aims to present key perspectives and summarize current evidence from metagenomic studies of salivary microbiota in relation to general health and systemic diseases. DESIGN: A narrative review of studies that described salivary microbiome composition in relation to various general health conditions was conducted and the main results were summarized. RESULTS: Currently available evidence shows salivary microbial patterns and fingerprints as related to a range of metabolic, autoimmune and immunodeficiency associated conditions, similar to albeit at a far lower scale than similar studies in the gut microbiome. CONCLUSIONS: Considering the relative ease of collection, emerging evidence of association with non-oral diseases may imply that saliva microbiome research may have potential diagnostic or prognostic value.
OBJECTIVE: The advent of high-throughput sequencing and 'omic' technologies is facilitating an 'open-ended' understanding of the human microbial community and its interplay with health. This commentary aims to present key perspectives and summarize current evidence from metagenomic studies of salivary microbiota in relation to general health and systemic diseases. DESIGN: A narrative review of studies that described salivary microbiome composition in relation to various general health conditions was conducted and the main results were summarized. RESULTS: Currently available evidence shows salivary microbial patterns and fingerprints as related to a range of metabolic, autoimmune and immunodeficiency associated conditions, similar to albeit at a far lower scale than similar studies in the gut microbiome. CONCLUSIONS: Considering the relative ease of collection, emerging evidence of association with non-oral diseases may imply that saliva microbiome research may have potential diagnostic or prognostic value.
Authors: Daniel J Morse; Ann Smith; Melanie J Wilson; Lucy Marsh; Lewis White; Raquel Posso; David J Bradshaw; Xiaoqing Wei; Michael A O Lewis; David W Williams Journal: Sci Rep Date: 2019-07-15 Impact factor: 4.379
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