Victor T Noronha1, Amauri J Paula2, Gabriela Durán3, Andre Galembeck4, Karina Cogo-Müller5, Michelle Franz-Montan6, Nelson Durán7. 1. Solid-Biological Interface Group (SolBIN), Department of Physics, Universidade Federal do Ceará, Fortaleza, CE, Brazil. 2. Solid-Biological Interface Group (SolBIN), Department of Physics, Universidade Federal do Ceará, Fortaleza, CE, Brazil. Electronic address: amaurijp@gmail.com. 3. Faculdade de Odontologia, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil. 4. Fundamental Chemistry Department, Universidade Federal de Pernambuco, Recife, PE, Brazil; Centro de Tecnologias Estratégicas do Nordeste (CETENE), Campus MCTI Nordeste, Recife, PE, Brazil. 5. Faculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas, Campinas, SP, Brazil; Department of Physiological Sciences, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Campinas, SP, Brazil. 6. Department of Physiological Sciences, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Campinas, SP, Brazil. Electronic address: michelle@fop.unicamp.br. 7. Department of Physiological Sciences, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Campinas, SP, Brazil; NanoBioss Laboratory, Universidade Estadual de Campinas, SP, Brazil; National Nanotechnology Laboratory (LNNano) CNPEM, Campinas, SP, Brazil.
Abstract
OBJECTIVE: Silver nanoparticles (AgNPs) have been extensively studied for their antimicrobial properties, which provide an extensive applicability in dentistry. Because of this increasing interest in AgNPs, the objective of this paper was to review their use in nanocomposites; implant coatings; pre-formulation with antimicrobial activity against cariogenic pathogens, periodontal biofilm, fungal pathogens and endodontic bacteria; and other applications such as treatment of oral cancer and local anesthesia. Recent achievements in the study of the mechanism of action and the most important toxicological aspects are also presented. METHODS: Systematic searches were carried out in Web of Science (ISI), Google, PubMed, SciFinder and EspaceNet databases with the keywords "silver nano* or AgNP*" and "dentist* or dental* or odontol*". RESULTS: A total of 155 peer-reviewed articles were reviewed. Most of them were published in the period of 2012-2017, demonstrating that this topic currently represents an important trend in dentistry research. In vitro studies reveal the excellent antimicrobial activity of AgNPs when associated with dental materials such as nanocomposites, acrylic resins, resin co-monomers, adhesives, intracanal medication, and implant coatings. Moreover, AgNPs were demonstrated to be interesting tools in the treatment of oral cancers due to their antitumor properties. SIGNIFICANCE: The literature indicates that AgNPs are a promising system with important features such as antimicrobial, anti-inflammatory and antitumor activity, and a potential carrier in sustained drug delivery. However, there are some aspects of the mechanisms of action of AgNPs, and some important toxicological aspects arising from the use of this system that must be completely elucidated.
OBJECTIVE:Silver nanoparticles (AgNPs) have been extensively studied for their antimicrobial properties, which provide an extensive applicability in dentistry. Because of this increasing interest in AgNPs, the objective of this paper was to review their use in nanocomposites; implant coatings; pre-formulation with antimicrobial activity against cariogenic pathogens, periodontal biofilm, fungal pathogens and endodontic bacteria; and other applications such as treatment of oral cancer and local anesthesia. Recent achievements in the study of the mechanism of action and the most important toxicological aspects are also presented. METHODS: Systematic searches were carried out in Web of Science (ISI), Google, PubMed, SciFinder and EspaceNet databases with the keywords "silver nano* or AgNP*" and "dentist* or dental* or odontol*". RESULTS: A total of 155 peer-reviewed articles were reviewed. Most of them were published in the period of 2012-2017, demonstrating that this topic currently represents an important trend in dentistry research. In vitro studies reveal the excellent antimicrobial activity of AgNPs when associated with dental materials such as nanocomposites, acrylic resins, resin co-monomers, adhesives, intracanal medication, and implant coatings. Moreover, AgNPs were demonstrated to be interesting tools in the treatment of oral cancers due to their antitumor properties. SIGNIFICANCE: The literature indicates that AgNPs are a promising system with important features such as antimicrobial, anti-inflammatory and antitumor activity, and a potential carrier in sustained drug delivery. However, there are some aspects of the mechanisms of action of AgNPs, and some important toxicological aspects arising from the use of this system that must be completely elucidated.
Authors: José Antonio Santos Souza; Debora Barros Barbosa; Jackeline Gallo do Amaral; Douglas Roberto Monteiro; Luiz Fernando Gorup; Francisco Nunes de Souza Neto; Renan Aparecido Fernandes; Gabriela Lopes Fernandes; Emerson Rodrigues de Camargo; Alessandra Marçal Agostinho; Alberto Carlos Botazzo Delbem Journal: Indian J Microbiol Date: 2019-03-19 Impact factor: 2.461
Authors: Maria Karollyna do Nascimento Silva Leandro; João Victor Barbosa Moura; Ana Carolina Justino de Araújo; Priscilla Ramos Freitas; Cicera Laura Roque Paulo; Amanda Karine de Sousa; Janaina Esmeraldo Rocha; Lívia Maria Garcia Leandro; Rakel Olinda Macedo da Silva; Clenilton Costa Dos Santos; Jaime Ribeiro-Filho; Cleânio da Luz Lima; Abolghasem Siyadatpanah; Zahra Seifi; Bonglee Kim; Henrique Douglas Melo Coutinho Journal: Bioinorg Chem Appl Date: 2022-07-09 Impact factor: 4.724
Authors: Ping Li; Christine Schille; Ernst Schweizer; Frank Rupp; Alexander Heiss; Claudia Legner; Ulrich E Klotz; Jürgen Geis-Gerstorfer; Lutz Scheideler Journal: Int J Mol Sci Date: 2018-03-07 Impact factor: 5.923
Authors: Abdulrahman A Balhaddad; Anmar A Kansara; Denise Hidan; Michael D Weir; Hockin H K Xu; Mary Anne S Melo Journal: Bioact Mater Date: 2018-12-18