| Literature DB >> 28778444 |
Israt Jahan1, Rijwan U Ahammad1, Kaniz S Farzana1, Mir M Khalid1, Mohammad B Islam2, Mohammad I Rahman1, Shamsun Nahar1, Yearul Kabir3, Quazi D Mohmmad4, Zhahirul Islam5.
Abstract
Guillain-Barré syndrome (GBS) is a post-infectious autoimmune polyneuropathy regulated by pro- and anti-inflammatory cytokines; TNFA polymorphisms may exert immune pathogenic roles in GBS. We assessed TNFA promoter region polymorphisms (-238G/A, -308G/A, -857C/T, -863C/A) in Bangladeshi patients with GBS (n=300) and healthy controls (n=300) by PCR-RFLP and ASO-PCR. TNFA -863CA was significantly associated with GBS disease susceptibility (P=0.0154) and disease severity (P=0.0492). TNFA -238A allele was more frequent among anti-ganglioside (GM1) antibody-positive patients (P=0.0092) and -863AA associated with AMAN subtype of GBS (P=0.0398). TNFA -863C/A may contribute to GBS severity and pathogenesis in Bangladeshi patients.Entities:
Keywords: Allele; Genotype; Guillain-Barré syndrome; Promoter region; SNPs; TNFA
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Year: 2017 PMID： 28778444 DOI： 10.1016/j.jneuroim.2017.06.005
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478