| Literature DB >> 28765045 |
Zhe Kong1, Xuechao Wan1, Yalong Zhang1, Pu Zhang1, Yingyi Zhang2, Xiaona Zhang3, Xiaoxiang Qi3, Hai Wu1, Jianfeng Huang4, Yao Li5.
Abstract
Prostate cancer (PCa) is one of the most commonly diagnosed cancers in males worldwide. Circular RNA (circRNA) is a unique class of RNA transcribed by RNA polymerase II characterized by jointing 3' and 5' ends together via exon or intron circularization. However, the molecular functions of circRNAs in prostate cancer have rarely been explored. In present study, we found circ-SMARCA5 was up-regulated in prostate cancer samples compared to match normal tissues. We also observed circ-SMARCA5 expression was significantly induced after DHT treatment. Functional experiments showed circ-SMARCA5 acted as an oncogene in prostate cancer by promoting cell cycle and inhibiting cell apoptosis. We thought this study provided useful information for exploring circRNAs as potential therapeutic and prognostic targets for prostate cancer.Entities:
Keywords: Androgen-responsive; Proliferation; Prostate cancer; circRNA; circSMARCA5
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Year: 2017 PMID： 28765045 DOI： 10.1016/j.bbrc.2017.07.162
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575