Rucha Diwakar Gore1, Sangeeta Jayant Palaskar2, Anirudha Ratnadeep Bartake3. 1. Postgraduate Student, Department of Oral Pathology and Microbiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, India. 2. Professor and Head, Department of Oral Pathology and Microbiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, India. 3. Reader, Department of Oral Pathology and Microbiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, India.
Abstract
INTRODUCTION: Oral squamous cell carcinoma is the sixth most common cancer worldwide and is one of the leading causes of death especially in developing countries like India. It is usually managed with the help of chemotherapeutic agents that are toxic not only to the tumor cells but also to normal cells in many ways. Whereas the traditional herbal medicines which are used from ancient days in India are generally known to be free of toxic effects and are effective. Wheatgrass is the young grass of the wheat plant 'Tritcumaestivum Linn', family Poaceae (Gramineae). It contains a number of vitamins, mineral, amino acids and vital enzymes, these play an important role in the anticancer approach of this herbal product. It is also called as 'green blood' because of its high content of chlorophyll, which bears a structural similarity to haemoglobin and this result in high oxygen supply to all the body tissues. AIM: To analyse the effect of the aqueous wheat grass extract on Oral Squamous Cell Carcinoma (OSCC) cell line by MTT assay. MATERIALS AND METHODS: 'KB cell line' (Mouth Epidermal Carcinoma Cells) was used for the present study. Aqueous extract of wheat grass was prepared in the institution. The aim of the study was to assess the effect of the aqueous wheat grass extract on KB cell line(OSCC) by MTT assay. RESULTS: A 41.4% of OSCC cell inhibition was observed at 1000 µg/ml dilution of aqueous wheatgrass extract in 24 hours. CONCLUSION: The aqueous extract of wheatgrass has an inhibitory effect on the oral cancer cell line proliferation.
INTRODUCTION:Oral squamous cell carcinoma is the sixth most common cancer worldwide and is one of the leading causes of death especially in developing countries like India. It is usually managed with the help of chemotherapeutic agents that are toxic not only to the tumor cells but also to normal cells in many ways. Whereas the traditional herbal medicines which are used from ancient days in India are generally known to be free of toxic effects and are effective. Wheatgrass is the young grass of the wheat plant 'Tritcumaestivum Linn', family Poaceae (Gramineae). It contains a number of vitamins, mineral, amino acids and vital enzymes, these play an important role in the anticancer approach of this herbal product. It is also called as 'green blood' because of its high content of chlorophyll, which bears a structural similarity to haemoglobin and this result in high oxygen supply to all the body tissues. AIM: To analyse the effect of the aqueous wheat grass extract on Oral Squamous Cell Carcinoma (OSCC) cell line by MTT assay. MATERIALS AND METHODS: 'KB cell line' (Mouth Epidermal Carcinoma Cells) was used for the present study. Aqueous extract of wheat grass was prepared in the institution. The aim of the study was to assess the effect of the aqueous wheat grass extract on KB cell line(OSCC) by MTT assay. RESULTS: A 41.4% of OSCC cell inhibition was observed at 1000 µg/ml dilution of aqueous wheatgrass extract in 24 hours. CONCLUSION: The aqueous extract of wheatgrass has an inhibitory effect on the oral cancer cell line proliferation.
Authors: Sunil D Kulkarni; Jai C Tilak; R Acharya; Nilima S Rajurkar; T P A Devasagayam; A V R Reddy Journal: Phytother Res Date: 2006-03 Impact factor: 5.878
Authors: Amy Fakhry Boushra; Asmaa Mohammed Elsayed; Noha Abdellatif Ibrahim; Maha Khaled Abdelwahed; Eman Ibrahim Ahmed Journal: Mol Biol Rep Date: 2019-07-11 Impact factor: 2.316