Augustine C Lee1, Rina M Bloch, William F Harvey, Jeffrey B Driban, Lori Lyn Price, Xingyi Han, Chenchen Wang. 1. From the Center for Complementary and Integrative Medicine, Division of Rheumatology, Tufts Medical Center, Boston, Massachusetts (ACL, WFH, JBD, XH, CW); Department of Physical Medicine and Rehabilitation, Tufts Medical Center, Boston, Massachusetts (RMB); Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts (LLP); and Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts (LLP).
Abstract
OBJECTIVES: Mobility activity modifications indicate early functional losses that act as precursors to future declines among community-dwelling older adults. However, there is scarce evidence on whether activity modifications indicate poorer physical health among adults with symptomatic osteoarthritis, a major cause of disability. Our purpose was to investigate whether patient-reported mobility activity modifications indicated poorer physical health among adults with symptomatic knee osteoarthritis. DESIGN: Secondary cross-sectional analysis of randomized trial data was performed. Preclinical Disability Questionnaire was used to group participants into the following three categories: difficulty, modified, and no difficulty walking/stair climbing. Kruskal Wallis and χ tests were used to compare clinical factors across groups. RESULTS: Among 121 participants (median age = 60 yrs; 73% female; 60% white), less than 10% had modified walking/stair climbing. Compared with those with no walking difficulty, participants with modified walking had significantly less balance (P = 0.01) and global health (P = 0.01) as well as greater knee pain (P = 0.05) and physical disability (P = 0.04). Those with modified stair climbing had significantly smaller walking distances (P = 0.03) compared with those with no difficulty stair climbing. CONCLUSIONS: Activity modifications may signal early impairments in physical health among people with symptomatic knee osteoarthritis. If confirmed, patient-reported activity modifications may enhance symptom evaluation in osteoarthritis and enable a better understanding of the disablement process.
RCT Entities:
OBJECTIVES: Mobility activity modifications indicate early functional losses that act as precursors to future declines among community-dwelling older adults. However, there is scarce evidence on whether activity modifications indicate poorer physical health among adults with symptomatic osteoarthritis, a major cause of disability. Our purpose was to investigate whether patient-reported mobility activity modifications indicated poorer physical health among adults with symptomatic knee osteoarthritis. DESIGN: Secondary cross-sectional analysis of randomized trial data was performed. Preclinical Disability Questionnaire was used to group participants into the following three categories: difficulty, modified, and no difficulty walking/stair climbing. Kruskal Wallis and χ tests were used to compare clinical factors across groups. RESULTS: Among 121 participants (median age = 60 yrs; 73% female; 60% white), less than 10% had modified walking/stair climbing. Compared with those with no walking difficulty, participants with modified walking had significantly less balance (P = 0.01) and global health (P = 0.01) as well as greater knee pain (P = 0.05) and physical disability (P = 0.04). Those with modified stair climbing had significantly smaller walking distances (P = 0.03) compared with those with no difficulty stair climbing. CONCLUSIONS: Activity modifications may signal early impairments in physical health among people with symptomatic knee osteoarthritis. If confirmed, patient-reported activity modifications may enhance symptom evaluation in osteoarthritis and enable a better understanding of the disablement process.
Authors: T E McAlindon; J B Driban; Y Henrotin; D J Hunter; G-L Jiang; S T Skou; S Wang; T Schnitzer Journal: Osteoarthritis Cartilage Date: 2015-05 Impact factor: 6.576
Authors: Louise Murphy; Todd A Schwartz; Charles G Helmick; Jordan B Renner; Gail Tudor; Gary Koch; Anca Dragomir; William D Kalsbeek; Gheorghe Luta; Joanne M Jordan Journal: Arthritis Rheum Date: 2008-09-15
Authors: Chenchen Wang; Maura D Iversen; Timothy McAlindon; William F Harvey; John B Wong; Roger A Fielding; Jeffrey B Driban; Lori Lyn Price; Ramel Rones; Tressa Gamache; Christopher H Schmid Journal: BMC Complement Altern Med Date: 2014-09-08 Impact factor: 3.659