PURPOSE: Totally implantable venous access ports (TIVAP) have been widely used for many years in the management of patients suffering from cancer. The implantation and long-term use of TIVAPs are associated with mechanical, thrombotic, and infectious complications. This is the first exhaustive prospective study of all complications occurring in a whole population on long-term follow-up and therefore allows an objective assessment to be made of the safety of TIVAPs. METHODS: We carried out a prospective single-center observational study. All adult patients with cancer who had a TIVAP implanted between January 1 and December 31, 2006 were registered. Early and late complications were recorded until the removal of the device, the patient's death, or until December 31, 2013. Exhaustive data concerning patients and TIVAP was recorded at time of implantation. RESULTS: Four hundred and ninety-three TIVAPs were implanted in 483 adult cancer patients and were followed during a period from 1 to 94 months (median = 18 months) representing a global quantity of 367,359 catheter-days. Eighty-seven complications were recorded (0.237/1000 catheter-days), including 37 infections (0.101/1000 catheter-days), 17 thrombotic events (0.046/1000 catheter-days), and 9 extravasations. Out of the 87 events, 62 (71.3%) occurred during the first year after implantation. Events were therefore extremely rare after 1 year. Thromboembolic and infectious complications were rare and no risk factors for these were found. CONCLUSIONS: This study demonstrates excellent tolerability, with only occasional complications. Most of these occurred during the year following implantation. A TIVAP may also be left in place for an extremely long time.
PURPOSE: Totally implantable venous access ports (TIVAP) have been widely used for many years in the management of patients suffering from cancer. The implantation and long-term use of TIVAPs are associated with mechanical, thrombotic, and infectious complications. This is the first exhaustive prospective study of all complications occurring in a whole population on long-term follow-up and therefore allows an objective assessment to be made of the safety of TIVAPs. METHODS: We carried out a prospective single-center observational study. All adult patients with cancer who had a TIVAP implanted between January 1 and December 31, 2006 were registered. Early and late complications were recorded until the removal of the device, the patient's death, or until December 31, 2013. Exhaustive data concerning patients and TIVAP was recorded at time of implantation. RESULTS: Four hundred and ninety-three TIVAPs were implanted in 483 adult cancerpatients and were followed during a period from 1 to 94 months (median = 18 months) representing a global quantity of 367,359 catheter-days. Eighty-seven complications were recorded (0.237/1000 catheter-days), including 37 infections (0.101/1000 catheter-days), 17 thrombotic events (0.046/1000 catheter-days), and 9 extravasations. Out of the 87 events, 62 (71.3%) occurred during the first year after implantation. Events were therefore extremely rare after 1 year. Thromboembolic and infectious complications were rare and no risk factors for these were found. CONCLUSIONS: This study demonstrates excellent tolerability, with only occasional complications. Most of these occurred during the year following implantation. A TIVAP may also be left in place for an extremely long time.
Entities:
Keywords:
Cancer chemotherapy; Complications; Infections; Long-term follow-up; Thromboses; Totally implantable venous access port
Authors: S Revel-Vilk; J Yacobovich; H Tamary; G Goldstein; S Nemet; M Weintraub; O Paltiel; G Kenet Journal: Cancer Date: 2010-09-01 Impact factor: 6.860
Authors: C Heibl; V Trommet; S Burgstaller; B Mayrbaeurl; C Baldinger; R Koplmüller; T Kühr; L Wimmer; J Thaler Journal: Eur J Cancer Care (Engl) Date: 2009-08-25 Impact factor: 2.520
Authors: R D Hull; J Hirsh; C J Carter; R M Jay; P E Dodd; P A Ockelford; G Coates; G J Gill; A G Turpie; D J Doyle; H R Buller; G E Raskob Journal: Ann Intern Med Date: 1983-06 Impact factor: 25.391
Authors: R Biffi; F Orsi; S Pozzi; U Pace; G Bonomo; L Monfardini; P Della Vigna; N Rotmensz; D Radice; M G Zampino; N Fazio; F de Braud; B Andreoni; A Goldhirsch Journal: Ann Oncol Date: 2009-01-29 Impact factor: 32.976
Authors: J S Groeger; A B Lucas; H T Thaler; H Friedlander-Klar; A E Brown; T E Kiehn; D Armstrong Journal: Ann Intern Med Date: 1993-12-15 Impact factor: 25.391
Authors: Augusto Cesar Maia Rio Lima Silveira; Paula Shelda Fonseca Fernandes; Danilo Rafael da Silva Fontinele; Rafael Everton Assunção Ribeiro da Costa; José Eduardo Prado Araújo; Wilson de Oliveira Sousa; Sabas Carlos Vieira Journal: J Vasc Bras Date: 2022-05-09