Jeffrey M Politsky1,2,3,4. 1. Northeast Regional Epilepsy Group, 95 Madison Ave, Suite 306, Morristown, NJ, 07960, USA. jpolitsky@epilepsygroup.com. 2. Atlantic Neuroscience Institute, Comprehensive Epilepsy Center, Overlook Medical Center, 99 Beauvoir Ave, Summit, NJ, 07902, USA. jpolitsky@epilepsygroup.com. 3. Comprehensive Pediatric Epilepsy Program, Morristown Medical Center, 100 Madison Ave., Morristown, NJ, 07960, USA. jpolitsky@epilepsygroup.com. 4. Department of Neurology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA. jpolitsky@epilepsygroup.com.
Abstract
PURPOSE OF REVIEW: The relationship of brain tumors and seizures remains poorly understood. This article is an overview of the epidemiology, etiology, and diagnostic and treatment approaches of tumor-related epilepsy primarily with regard to glial-based tumors, the most commonly considered brain tumor in this field. RECENT FINDINGS: Over the past many years, several novel etiologic mechanisms to explain how tumors induce seizures have been developed, which this article reviews, including the roles of glutamate-induced excitotoxicity, matrix metalloproteinases, isocitrate dehydrogenase, methylguanine methyltransferase, and functional network connectivity. As well, diagnostic and treatment approaches vary considerably. This article summarizes the evidence and provides the rationale for a reconsideration of how we deliver pre-operative, peri-operative, and post-operative care to these patients. Patients with brain tumors and epilepsy are a very challenging subgroup of patients, which necessitates not just a thorough understanding of the current principles regarding tumor-related epilepsy but also the development of collaborative research to advance our knowledge even further, and a concerted effort to develop a standardized, multi-disciplinary clinical approach to improve the care of these patients.
PURPOSE OF REVIEW: The relationship of brain tumors and seizures remains poorly understood. This article is an overview of the epidemiology, etiology, and diagnostic and treatment approaches of tumor-related epilepsy primarily with regard to glial-based tumors, the most commonly considered brain tumor in this field. RECENT FINDINGS: Over the past many years, several novel etiologic mechanisms to explain how tumors induce seizures have been developed, which this article reviews, including the roles of glutamate-induced excitotoxicity, matrix metalloproteinases, isocitrate dehydrogenase, methylguanine methyltransferase, and functional network connectivity. As well, diagnostic and treatment approaches vary considerably. This article summarizes the evidence and provides the rationale for a reconsideration of how we deliver pre-operative, peri-operative, and post-operative care to these patients. Patients with brain tumors and epilepsy are a very challenging subgroup of patients, which necessitates not just a thorough understanding of the current principles regarding tumor-related epilepsy but also the development of collaborative research to advance our knowledge even further, and a concerted effort to develop a standardized, multi-disciplinary clinical approach to improve the care of these patients.
Authors: Jörg Wellmer; Ferdinand von der Groeben; Ute Klarmann; Christian Weber; Christian E Elger; Horst Urbach; Hans Clusmann; Marec von Lehe Journal: Epilepsia Date: 2012-06-18 Impact factor: 5.864
Authors: J Dong; L K Opresko; P J Dempsey; D A Lauffenburger; R J Coffey; H S Wiley Journal: Proc Natl Acad Sci U S A Date: 1999-05-25 Impact factor: 11.205
Authors: Kimon Bekelis; Tarek A Radwan; Atman Desai; Ziev B Moses; Vijay M Thadani; Barbara C Jobst; Krzysztof A Bujarski; Terrance M Darcey; David W Roberts Journal: J Neurosurg Date: 2012-10-12 Impact factor: 5.115
Authors: Mèlanie S M van Breemen; R M Rijsman; M J B Taphoorn; R Walchenbach; H Zwinkels; Charles J Vecht Journal: J Neurol Date: 2009-05-12 Impact factor: 4.849
Authors: Laura M Lynam; Mark K Lyons; Joseph F Drazkowski; Joseph I Sirven; Katherine H Noe; Richard S Zimmerman; James A Wilkens Journal: Clin Neurol Neurosurg Date: 2007-06-29 Impact factor: 1.876
Authors: Marco Zoccarato; Lucia Nardetto; Anna Maria Basile; Bruno Giometto; Vittorina Zagonel; Giuseppe Lombardi Journal: Front Oncol Date: 2021-03-22 Impact factor: 6.244
Authors: Fernando Santos-Pinheiro; Mingjeong Park; Diane Liu; Lawrence N Kwong; Savannah Cruz; Nicholas B Levine; Barbara J O'Brien; Merry Chen Journal: Neurooncol Pract Date: 2018-07-09
Authors: Ryan T Merrell; Kelly Claire Simon; Nina Martinez; Rosa Maria Vazquez; Bryce Hadsell; Alexander Epshteyn; Gary Wilk; Roberta Frigerio; Demetrius M Maraganore Journal: Mayo Clin Proc Innov Qual Outcomes Date: 2021-06-05