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Literature DB >> 28752854

CTCF fences make good neighbours.

Abstract

CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the α-globin enhancers is now shown to result in inappropriate activation of neighbouring genes. Intra-TAD enhancer insulation might be broadly important for tissue specificity of enhancers.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2017 PMID： 28752854 PMCID： PMC6247897 DOI： 10.1038/ncb3584

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

15 in total

1. Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition.

Authors: Karen M Lower; Jim R Hughes; Marco De Gobbi; Shirley Henderson; Vip Viprakasit; Chris Fisher; Anne Goriely; Helena Ayyub; Jackie Sloane-Stanley; Douglas Vernimmen; Cordelia Langford; David Garrick; Richard J Gibbons; Douglas R Higgs
Journal: Proc Natl Acad Sci U S A Date: 2009-12-03 Impact factor: 11.205

2. Variegated gene expression caused by cell-specific long-range DNA interactions.

Authors: Daan Noordermeer; Elzo de Wit; Petra Klous; Harmen van de Werken; Marieke Simonis; Melissa Lopez-Jones; Bert Eussen; Annelies de Klein; Robert H Singer; Wouter de Laat
Journal: Nat Cell Biol Date: 2011-06-26 Impact factor: 28.824

3. Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.

Authors: Darío G Lupiáñez; Katerina Kraft; Verena Heinrich; Peter Krawitz; Francesco Brancati; Eva Klopocki; Denise Horn; Hülya Kayserili; John M Opitz; Renata Laxova; Fernando Santos-Simarro; Brigitte Gilbert-Dussardier; Lars Wittler; Marina Borschiwer; Stefan A Haas; Marco Osterwalder; Martin Franke; Bernd Timmermann; Jochen Hecht; Malte Spielmann; Axel Visel; Stefan Mundlos
Journal: Cell Date: 2015-05-07 Impact factor: 41.582

4. Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.

Authors: Lars L P Hanssen; Mira T Kassouf; A Marieke Oudelaar; Daniel Biggs; Chris Preece; Damien J Downes; Matthew Gosden; Jacqueline A Sharpe; Jacqueline A Sloane-Stanley; Jim R Hughes; Benjamin Davies; Douglas R Higgs
Journal: Nat Cell Biol Date: 2017-07-24 Impact factor: 28.824

5. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping.

Authors: Suhas S P Rao; Miriam H Huntley; Neva C Durand; Elena K Stamenova; Ivan D Bochkov; James T Robinson; Adrian L Sanborn; Ido Machol; Arina D Omer; Eric S Lander; Erez Lieberman Aiden
Journal: Cell Date: 2014-12-11 Impact factor: 41.582

Review 6. Enhancer function: mechanistic and genome-wide insights come together.

Authors: Jennifer L Plank; Ann Dean
Journal: Mol Cell Date: 2014-07-03 Impact factor: 17.970

7. Activation of proto-oncogenes by disruption of chromosome neighborhoods.

Authors: Denes Hnisz; Abraham S Weintraub; Daniel S Day; Anne-Laure Valton; Rasmus O Bak; Charles H Li; Johanna Goldmann; Bryan R Lajoie; Zi Peng Fan; Alla A Sigova; Jessica Reddy; Diego Borges-Rivera; Tong Ihn Lee; Rudolf Jaenisch; Matthew H Porteus; Job Dekker; Richard A Young
Journal: Science Date: 2016-03-03 Impact factor: 47.728

CTCF fences make good neighbours.

1. Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition.

2. Variegated gene expression caused by cell-specific long-range DNA interactions.

3. Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.

4. Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.

5. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping.

Review 6. Enhancer function: mechanistic and genome-wide insights come together.

7. Activation of proto-oncogenes by disruption of chromosome neighborhoods.

8. Topological domains in mammalian genomes identified by analysis of chromatin interactions.

9. CTCF-mediated topological boundaries during development foster appropriate gene regulation.

10. Multiplexed analysis of chromosome conformation at vastly improved sensitivity.

1. Modification of Nuclear Compartments and the 3D Genome in the Course of a Viral Infection.

Review 2. Androgen receptor signaling and spatial chromatin organization in castration-resistant prostate cancer.

Review 3. Understanding breast cancer heterogeneity through non-genetic heterogeneity.