Tue Kjølhede1, Susanne Siemonsen2, Damian Wenzel2, Jan-Patrick Stellmann2, Steffen Ringgaard3, Bodil Ginnerup Pedersen4, Egon Stenager5, Thor Petersen6, Kristian Vissing1, Christoph Heesen7, Ulrik Dalgas1. 1. Section for Sport Science, Department of Public Health, Aarhus University, Aarhus C, Denmark. 2. Section of MS Imaging, Department of Diagnostic and Interventional Neuroradiology and Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 3. The MR Research Centre, Aarhus University Hospital, Aarhus N, Denmark. 4. Department of Radiology, Aarhus University Hospital, Aarhus N, Denmark. 5. Department of Regional Health Research, University of Southern Denmark, Odense C, Denmark/The Multiple Sclerosis Clinic of Southern Jutland (Sønderborg, Kolding, Esbjerg), Department of Neurology, Sygehus Sønderjylland, Sønderborg, Denmark. 6. The Multiple Sclerosis Clinic, Department of Neurology, Aarhus University Hospital, Aarhus C, Denmark. 7. Institute of Neuroimmunology and Multiple Sclerosis (INIMS) and Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Abstract
BACKGROUND: Multiple sclerosis (MS) is characterised by accelerated brain atrophy, which relates to disease progression. Previous research shows that progressive resistance training (PRT) can counteract brain atrophy in other populations. OBJECTIVE: To evaluate the effects of PRT by magnetic resonance imaging (MRI) and clinical measures of disease progression in people with MS. METHODS: This study was a 24-week randomised controlled cross-over trial, including a Training ( n = 18, 24 weeks of PRT followed by self-guided physical activity) and Waitlist group ( n = 17, 24 weeks of habitual lifestyle followed by PRT). Assessments included disability measures and MRI (lesion load, global brain volume, percentage brain volume change (PBVC) and cortical thickness). RESULTS: While the MS Functional Composite score improved, Expanded Disability Status Scale, lesion load and global brain volumes did not differ between groups. PBVC tended to differ between groups and higher absolute cortical thickness values were observed in 19 of 74 investigated cortical regions after PRT. Observed changes were confirmed and reproduced when comparing relative cortical thickness changes between groups for four areas: anterior cingulate gyrus, temporal pole, orbital sulcus and inferior temporal sulcus. CONCLUSION: PRT seem to induce an increase in cortical thickness, indicating that PRT have a neuroprotective or even neuroregenerative effect in relapsing-remitting MS.
RCT Entities:
BACKGROUND:Multiple sclerosis (MS) is characterised by accelerated brain atrophy, which relates to disease progression. Previous research shows that progressive resistance training (PRT) can counteract brain atrophy in other populations. OBJECTIVE: To evaluate the effects of PRT by magnetic resonance imaging (MRI) and clinical measures of disease progression in people with MS. METHODS: This study was a 24-week randomised controlled cross-over trial, including a Training ( n = 18, 24 weeks of PRT followed by self-guided physical activity) and Waitlist group ( n = 17, 24 weeks of habitual lifestyle followed by PRT). Assessments included disability measures and MRI (lesion load, global brain volume, percentage brain volume change (PBVC) and cortical thickness). RESULTS: While the MS Functional Composite score improved, Expanded Disability Status Scale, lesion load and global brain volumes did not differ between groups. PBVC tended to differ between groups and higher absolute cortical thickness values were observed in 19 of 74 investigated cortical regions after PRT. Observed changes were confirmed and reproduced when comparing relative cortical thickness changes between groups for four areas: anterior cingulate gyrus, temporal pole, orbital sulcus and inferior temporal sulcus. CONCLUSION: PRT seem to induce an increase in cortical thickness, indicating that PRT have a neuroprotective or even neuroregenerative effect in relapsing-remitting MS.
Authors: Brian Mark Lozinski; Luiz Gustavo Nogueira de Almeida; Claudia Silva; Yifei Dong; Dennis Brown; Sameeksha Chopra; V Wee Yong; Antoine Dufour Journal: Sci Rep Date: 2021-03-31 Impact factor: 4.379
Authors: Luis Andreu-Caravaca; Domingo Ramos-Campo; Pedro Manonelles; Oriol Abellán-Aynés; Linda H Chung; Jacobo Á Rubio-Arias Journal: Physiol Behav Date: 2021-03-19
Authors: Jan-Patrick Stellmann; Adil Maarouf; Karl-Heinz Schulz; Lisa Baquet; Jana Pöttgen; Stefan Patra; Iris-Katharina Penner; Susanne Gellißen; Gesche Ketels; Pierre Besson; Jean-Philippe Ranjeva; Maxime Guye; Guido Nolte; Andreas K Engel; Bertrand Audoin; Christoph Heesen; Stefan M Gold Journal: Front Hum Neurosci Date: 2020-06-30 Impact factor: 3.169