Denis Poddubnyy1,2, Joachim Sieper3. 1. Department of Gastroenterology, Infectiology and Rheumatology, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany. denis.poddubnyy@charite.de. 2. German Rheumatism Research Centre, Berlin, Germany. denis.poddubnyy@charite.de. 3. Department of Gastroenterology, Infectiology and Rheumatology, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Abstract
PURPOSE OF THE REVIEW: The purpose of this review is to discuss new evidence explaining the progress from bony inflammation over repair tissue to new bone formation in axial spondyloartrhitis and its correlations in imaging and histology of the bone. RECENT FINDINGS: Data from imaging, histology and treatment interventions indicates that the disease starts with inflammation, followed by replacement of subchondral bone marrow by repair tissue which presence is crucial for the stimulation of new bone formation. The magnetic resonance imaging (MRI) sequences of STIR and T1 are currently the most commonly used imaging techniques to follow this process; explanations are offered for the limited sensitivity to detect these bony changes on MRI in their different phases. Early and effective anti-inflammatory treatment is crucial for the prevention of long-term ankylosis. Whether there are currently also treatment options targeting new bone formation in these patients directly is less clear.
PURPOSE OF THE REVIEW: The purpose of this review is to discuss new evidence explaining the progress from bony inflammation over repair tissue to new bone formation in axial spondyloartrhitis and its correlations in imaging and histology of the bone. RECENT FINDINGS: Data from imaging, histology and treatment interventions indicates that the disease starts with inflammation, followed by replacement of subchondral bone marrow by repair tissue which presence is crucial for the stimulation of new bone formation. The magnetic resonance imaging (MRI) sequences of STIR and T1 are currently the most commonly used imaging techniques to follow this process; explanations are offered for the limited sensitivity to detect these bony changes on MRI in their different phases. Early and effective anti-inflammatory treatment is crucial for the prevention of long-term ankylosis. Whether there are currently also treatment options targeting new bone formation in these patients directly is less clear.
Authors: Denis Poddubnyy; Hildrun Haibel; Joachim Listing; Elisabeth Märker-Hermann; Henning Zeidler; Jürgen Braun; Joachim Sieper; Martin Rudwaleit Journal: Arthritis Rheum Date: 2012-05
Authors: X Baraliakos; F Heldmann; J Callhoff; J Listing; T Appelboom; J Brandt; F Van den Bosch; M Breban; Gr Burmester; M Dougados; P Emery; H Gaston; M Grunke; I E Van Der Horst-Bruinsma; R Landewé; M Leirisalo-Repo; J Sieper; K De Vlam; D Pappas; U Kiltz; D Van Der Heijde; J Braun Journal: Ann Rheum Dis Date: 2013-07-14 Impact factor: 19.103
Authors: Pedro Machado; Robert Landewé; Jürgen Braun; Kay-Geert A Hermann; Daniel Baker; Désirée van der Heijde Journal: Ann Rheum Dis Date: 2010-05-24 Impact factor: 19.103
Authors: Xenofon Baraliakos; Sebastian Kruse; Simone E Auteri; Natasha de Peyrecave; Tommi Nurminen; Thomas Kumke; Bengt Hoepken; Jürgen Braun Journal: Rheumatology (Oxford) Date: 2022-07-06 Impact factor: 7.046