Matthew D Ettleson1, Corey J Lager1, Andrew T Kraftson1, Nazanene H Esfandiari1, Elif A Oral2. 1. Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. 2. Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA - eliforal@umich.edu.
Abstract
INTRODUCTION: Roux-en-Y gastric bypass (GB) and sleeve gastrectomy (SG) are the most commonly performed metabolic surgeries and are highly effective for the treatment of obesity and related comorbidities. In this narrative review, recent studies of at least two years of follow-up directly comparing outcomes between GB and SG are reviewed to assess the efficacy of each procedure in weight loss and diabetes remission, as well as resulting quality of life (QoL) assessment and micronutrient deficiencies. EVIDENCE ACQUISITION: A systematic search of the literature of PubMed using MeSH terms and key words was performed. EVIDENCE SYNTHESIS: Forty recent studies comparing GB and SG including 208,556 patients are included in this narrative review. Most studies demonstrate significantly greater weight loss after GB compared to SG. There is some evidence that GB may lead to greater proportion of remission of diabetes mellitus (DM), but the majority of studies found no significant difference at longer follow-up. There is some evidence of greater rates of vitamin D and B12 deficiencies following GB. There were no significant differences in QoL assessments between SG and GB. CONCLUSIONS: A review of moderate and long-term studies directly comparing SG and GB suggests a greater degree of weight loss with GB. There is some but limited evidence the GB is more likely to induce DM remission, while increasing the risk of specific micronutrient deficiencies.
INTRODUCTION: Roux-en-Y gastric bypass (GB) and sleeve gastrectomy (SG) are the most commonly performed metabolic surgeries and are highly effective for the treatment of obesity and related comorbidities. In this narrative review, recent studies of at least two years of follow-up directly comparing outcomes between GB and SG are reviewed to assess the efficacy of each procedure in weight loss and diabetes remission, as well as resulting quality of life (QoL) assessment and micronutrient deficiencies. EVIDENCE ACQUISITION: A systematic search of the literature of PubMed using MeSH terms and key words was performed. EVIDENCE SYNTHESIS: Forty recent studies comparing GB and SG including 208,556 patients are included in this narrative review. Most studies demonstrate significantly greater weight loss after GB compared to SG. There is some evidence that GB may lead to greater proportion of remission of diabetes mellitus (DM), but the majority of studies found no significant difference at longer follow-up. There is some evidence of greater rates of vitamin D and B12 deficiencies following GB. There were no significant differences in QoL assessments between SG and GB. CONCLUSIONS: A review of moderate and long-term studies directly comparing SG and GB suggests a greater degree of weight loss with GB. There is some but limited evidence the GB is more likely to induce DM remission, while increasing the risk of specific micronutrient deficiencies.
Authors: Catarina Osório; Diogo Silva; Marta Guimarães; Rui F Almeida; António Reis; Samuel Cardoso; Sofia S Pereira; Mariana P Monteiro; Mário Nora Journal: Obes Surg Date: 2021-05-22 Impact factor: 4.129
Authors: Elina Akalestou; Livia Lopez-Noriega; Ioannis Christakis; Ming Hu; Alexander D Miras; Isabelle Leclerc; Guy A Rutter Journal: Front Endocrinol (Lausanne) Date: 2022-09-29 Impact factor: 6.055
Authors: Corey J Lager; Nazanene H Esfandiari; Yingying Luo; Angela R Subauste; Andrew T Kraftson; Morton B Brown; Oliver A Varban; Rasimcan Meral; Ruth B Cassidy; Catherine K Nay; Amy L Lockwood; Darlene Bellers; Colleen M Buda; Elif A Oral Journal: Obes Surg Date: 2018-11 Impact factor: 4.129