Literature DB >> 28748664

Long-term efficient control of SIV infection in macaques is associated with an intact intestinal barrier.

Maria Daskalaki1, Berit Neumann1, Antonina Klippert1, Kerstin Mätz-Rensing2, Franz-Josef Kaup2, Christiane Stahl-Hennig1.   

Abstract

Hallmarks of SIV infection are early depletion of gut CD4 T cells and diminished intestinal integrity. Comprehensive studies on colon biopsies of SIV-infected macaques efficiently controlling infection revealed that in contrast to viremic and failing controllers, elite controllers show preserved CD4 T cells, and low viral load, apoptosis, and inflammation.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  CD4 depletion; apoptosis; colon; immune activation; microbial translocation; simian immunodeficiency virus

Mesh：

Year:  2017        PMID： 28748664     DOI： 10.1111/jmp.12294

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


  2 in total

1.  DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections.

Authors:  Simon P Jochems; Beatrice Jacquelin; Nicolas Tchitchek; Florence Busato; Fabien Pichon; Nicolas Huot; Yi Liu; Mickaël J Ploquin; Elodie Roché; Rémi Cheynier; Nathalie Dereuddre-Bosquet; Christiane Stahl-Henning; Roger Le Grand; Jorg Tost; Michaela Müller-Trutwin
Journal:  Clin Epigenetics       Date:  2020-12-09       Impact factor: 6.551

2.  SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.

Authors:  Nicolas Huot; Philippe Rascle; Caroline Petitdemange; Vanessa Contreras; Christina M Stürzel; Eduard Baquero; Justin L Harper; Caroline Passaes; Rachel Legendre; Hugo Varet; Yoann Madec; Ulrike Sauermann; Christiane Stahl-Hennig; Jacob Nattermann; Asier Saez-Cirion; Roger Le Grand; R Keith Reeves; Mirko Paiardini; Frank Kirchhoff; Beatrice Jacquelin; Michaela Müller-Trutwin
Journal:  Nat Commun       Date:  2021-02-24       Impact factor: 14.919
  2 in total

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