| Literature DB >> 33627642 |
Nicolas Huot1, Philippe Rascle1,2, Caroline Petitdemange1, Vanessa Contreras3, Christina M Stürzel4, Eduard Baquero5, Justin L Harper6, Caroline Passaes1, Rachel Legendre7, Hugo Varet8, Yoann Madec9, Ulrike Sauermann10, Christiane Stahl-Hennig10, Jacob Nattermann11, Asier Saez-Cirion1, Roger Le Grand3, R Keith Reeves12, Mirko Paiardini6,13, Frank Kirchhoff4, Beatrice Jacquelin1, Michaela Müller-Trutwin14.
Abstract
Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of SIVagm infection in secondary lymphoid tissues. We demonstrate that SIVagm infection induces the expansion of terminally differentiated NKG2alow NK cells in secondary lymphoid organs displaying an adaptive transcriptional profile and increased MHC-E-restricted cytotoxicity in response to SIV Env peptides while expressing little IFN-γ. Such NK cell differentiation was lacking in SIVmac-infected macaques. Adaptive NK cells displayed no increased NKG2C expression. This study reveals a previously unknown profile of NK cell adaptation to a viral infection, thus accelerating strategies toward NK-cell directed therapies and viral control in tissues.Entities:
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Year: 2021 PMID： 33627642 PMCID： PMC7904927 DOI： 10.1038/s41467-021-21402-1
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919