Literature DB >> 2874849

Autocrine growth of interleukin 2-producing leukemic cells in a patient with adult T cell leukemia.

N Arima, Y Daitoku, S Ohgaki, J Fukumori, H Tanaka, Y Yamamoto, K Fujimoto, K Onoue.   

Abstract

Leukemic cells in the peripheral blood of a patient with adult T cell leukemia (ATL), which expressed the Tac antigen/interleukin 2 (IL2) receptor, were investigated in vitro for autocrine growth by IL 2. The cells showed spontaneous proliferation in mitogen-free medium. The spontaneous proliferation of the cells was inhibited by monoclonal anti-IL 2 or anti-Tac antibody. These cells were found to produce messenger RNA for IL 2 and secrete IL 2 during short-term culture in the same medium. Recombinant IL 2 and IL 2 secreted by the cells enhanced the proliferation of the cells in a dose-dependent manner when added to the initial culture. These findings demonstrate that an autocrine mechanism by IL 2 is involved in the proliferation of ATL cells during short-term culture.

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Year:  1986        PMID： 2874849

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  25 in total

1.  Temporal regulation of viral and cellular gene expression during human T-lymphotropic virus type I-mediated lymphocyte immortalization.

Authors:  J T Kimata; L Ratner
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

2.  Stable expression of the tax gene of type I human T-cell leukemia virus in human T cells activates specific cellular genes involved in growth.

Authors:  Y Wano; M Feinberg; J B Hosking; H Bogerd; W C Greene
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

3.  Mechanism of autocrine stimulation in hematopoietic cells producing interleukin-3 after retrovirus-mediated gene transfer.

Authors:  T M Browder; J S Abrams; P M Wong; A W Nienhuis
Journal:  Mol Cell Biol       Date:  1989-01       Impact factor: 4.272

4.  Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

Authors:  M Siekevitz; M B Feinberg; N Holbrook; F Wong-Staal; W C Greene
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

5.  Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat.

Authors:  K Nagata; K Ohtani; M Nakamura; K Sugamura
Journal:  J Virol       Date:  1989-08       Impact factor: 5.103

6.  Expression of p55 (Tac) interleukin-2 receptor (IL-2R), but not p75 IL-2R, in cultured H-RS cells and H-RS cells in tissues.

Authors:  S M Hsu; C K Tseng; P L Hsu
Journal:  Am J Pathol       Date:  1990-04       Impact factor: 4.307

7.  Constitutive IL-2 expression in HTLV-I-infected leukaemic T cell lines.

Authors:  J P Farcet; F Lebargy; C Lavignac; P Gaulard; A Dautry; L Gazzolo; P H Roméo; W Vainchenker
Journal:  Clin Exp Immunol       Date:  1991-06       Impact factor: 4.330

8.  Proliferative response of Tax1-transduced primary human T cells to anti-CD3 antibody stimulation by an interleukin-2-independent pathway.

Authors:  T Akagi; K Shimotohno
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

9.  Constitutive activation of the interleukin 2 gene in the induction of spontaneous in vitro transformation and tumorigenicity of T cells.

Authors:  M Nagarkatti; M Hassuneh; A Seth; K Manickasundari; P S Nagarkatti
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

10.  IL-2 mRNA expression in Tac-positive malignant lymphomas.

Authors:  M Peuchmaur; D Emilie; M C Crevon; P Solal-Celigny; M C Maillot; G Lemaigre; P Galanaud
Journal:  Am J Pathol       Date:  1990-02       Impact factor: 4.307
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