Literature DB >> 28748239

Phototoxicity of strained Ru(ii) complexes: is it the metal complex or the dissociating ligand?

Daniel F Azar1, Hassib Audi, Stephanie Farhat, Mirvat El-Sibai, Ralph J Abi-Habib, Rony S Khnayzer.   

Abstract

A photochemically dissociating ligand in Ru(bpy)2(dmphen)Cl2 [bpy = 2,2'-bipyridine; dmphen = 2,9-dimethyl-1,10-phenanthroline] was found to be more cytotoxic on the ML-2 Acute Myeloid Leukemia cell line than Ru(bpy)2(H2O)22+ and prototypical cisplatin. Our findings illustrate the potential potency of diimine ligands in photoactivatable Ru(ii) complexes.

Entities:  

Year:  2017        PMID： 28748239     DOI： 10.1039/c7dt02255g

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  10 in total

1.  Photochemical and Photobiological Activity of Ru(II) Homoleptic and Heteroleptic Complexes Containing Methylated Bipyridyl-type Ligands.

Authors:  Lars Kohler; Leona Nease; Pascal Vo; Jenna Garofolo; David K Heidary; Randolph P Thummel; Edith C Glazer
Journal:  Inorg Chem       Date:  2017-09-26       Impact factor: 5.165

2.  Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(ii) polypyridyl complex.

Authors:  Stephanie Mehanna; Najwa Mansour; Hassib Audi; Kikki Bodman-Smith; Mohamad A Mroueh; Robin I Taleb; Costantine F Daher; Rony S Khnayzer
Journal:  RSC Adv       Date:  2019-06-03       Impact factor: 4.036

3.  Anticancer Agent with Inexplicable Potency in Extreme Hypoxia: Characterizing a Light-Triggered Ruthenium Ubertoxin.

Authors:  Houston D Cole; John A Roque; Ge Shi; Liubov M Lifshits; Elamparuthi Ramasamy; Patrick C Barrett; Rachel O Hodges; Colin G Cameron; Sherri A McFarland
Journal:  J Am Chem Soc       Date:  2021-12-09       Impact factor: 16.383

Review 4.  Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds.

Authors:  Elizabeth T Papish; Olaitan E Oladipupo
Journal:  Curr Opin Chem Biol       Date:  2022-04-25       Impact factor: 8.972

5.  Intraligand Excited States Turn a Ruthenium Oligothiophene Complex into a Light-Triggered Ubertoxin with Anticancer Effects in Extreme Hypoxia.

Authors:  John A Roque Iii; Houston D Cole; Patrick C Barrett; Liubov M Lifshits; Rachel O Hodges; Susy Kim; Gagan Deep; Antonio Francés-Monerris; Marta E Alberto; Colin G Cameron; Sherri A McFarland
Journal:  J Am Chem Soc       Date:  2022-04-28       Impact factor: 16.383

6.  New Heteroleptic Ruthenium(II) Complexes with Sulfamethoxypyridazine and Diimines as Potential Antitumor Agents.

Authors:  Ariane C C de Melo; Jaime M S V P Santana; Kelen J R C Nunes; Bernardo L Rodrigues; Nathalia Castilho; Philipe Gabriel; Adolfo H Moraes; Mayra de A Marques; Guilherme A P de Oliveira; Ívina P de Souza; Hernán Terenzi; Elene C Pereira-Maia
Journal:  Molecules       Date:  2019-06-07       Impact factor: 4.411

7.  Ruthenium-based PACT agents based on bisquinoline chelates: synthesis, photochemistry, and cytotoxicity.

Authors:  Anja Busemann; Ingrid Flaspohler; Xue-Quan Zhou; Claudia Schmidt; Sina K Goetzfried; Vincent H S van Rixel; Ingo Ott; Maxime A Siegler; Sylvestre Bonnet
Journal:  J Biol Inorg Chem       Date:  2021-08-10       Impact factor: 3.358

Review 8.  Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes.

Authors:  Austin C Hachey; Dmytro Havrylyuk; Edith C Glazer
Journal:  Curr Opin Chem Biol       Date:  2021-03-30       Impact factor: 8.822

9.  Bacterial Cytological Profiling Reveals the Mechanism of Action of Anticancer Metal Complexes.

Authors:  Yang Sun; David K Heidary; Zhihui Zhang; Christopher I Richards; Edith C Glazer
Journal:  Mol Pharm       Date:  2018-06-30       Impact factor: 4.939

10.  Human Recombinant Arginase I [HuArgI (Co)-PEG5000]-Induced Arginine Depletion Inhibits Colorectal Cancer Cell Migration and Invasion.

Authors:  Houssam Al-Koussa; Maria Al-Haddad; Ralph Abi-Habib; Mirvat El-Sibai
Journal:  Int J Mol Sci       Date:  2019-11-29       Impact factor: 5.923
  10 in total

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