AIMS: The present study set out to investigate the relation of the high-density lipoprotein cholesterol (HDL-C) level to cognitive performance and its interplay with key markers of cognitive reserve in a large sample of older adults. METHODS: We assessed tests of working memory, immediate and delayed cued recall in 701 older adults from Amazonas, Brazil. The HDL-C level was derived from fasting blood samples. In addition, we interviewed individuals on their education, past occupation, and cognitive leisure activity. RESULTS: A critically low HDL-C level (<40 mg/dL) was significantly related to lower performance in working memory, immediate and delayed cued recall. Moderation analyses suggested that the relations of the HDL-C level to working memory and delayed cued recall were negligible in individuals with longer education, a higher cognitive level of the job, and greater engagement in cognitive leisure activity. CONCLUSION: Cognitive reserve accumulated during the life course may reduce the detrimental influences of a critically low HDL-C level on cognitive functioning in old age.
AIMS: The present study set out to investigate the relation of the high-density lipoprotein cholesterol (HDL-C) level to cognitive performance and its interplay with key markers of cognitive reserve in a large sample of older adults. METHODS: We assessed tests of working memory, immediate and delayed cued recall in 701 older adults from Amazonas, Brazil. The HDL-C level was derived from fasting blood samples. In addition, we interviewed individuals on their education, past occupation, and cognitive leisure activity. RESULTS: A critically low HDL-C level (<40 mg/dL) was significantly related to lower performance in working memory, immediate and delayed cued recall. Moderation analyses suggested that the relations of the HDL-C level to working memory and delayed cued recall were negligible in individuals with longer education, a higher cognitive level of the job, and greater engagement in cognitive leisure activity. CONCLUSION: Cognitive reserve accumulated during the life course may reduce the detrimental influences of a critically low HDL-C level on cognitive functioning in old age.
Authors: Melissa Lamar; Ramon A Durazo-Arvizu; Carlos J Rodriguez; Robert C Kaplan; Marisa J Perera; Jianwen Cai; Rebeca A Espinoza Giacinto; Hector M González; Martha L Daviglus Journal: J Int Neuropsychol Soc Date: 2019-09-23 Impact factor: 2.892
Authors: Priyanthi B Gjerde; Carmen E Simonsen; Trine V Lagerberg; Nils E Steen; Torill Ueland; Ole A Andreassen; Vidar M Steen; Ingrid Melle Journal: Eur Arch Psychiatry Clin Neurosci Date: 2019-04-27 Impact factor: 5.270
Authors: Élvio Rúbio Gouveia; Bruna R Gouveia; Adilson Marques; Miguel Peralta; Cíntia França; Alex Lima; Alderlane Campos; Jefferson Jurema; Matthias Kliegel; Andreas Ihle Journal: Int J Environ Res Public Health Date: 2021-02-01 Impact factor: 3.390