Jie Fan1, Mingtian Zhong2, Jun Gan3, Wanting Liu3, Chaoyang Niu3, Haiyan Liao4, Hongchun Zhang4, Jinyao Yi3, Raymond C K Chan5, Changlian Tan6, Xiongzhao Zhu7. 1. Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Medical Psychological Institute of Central South University, Changsha, Hunan 410011, China. 2. Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, Guangdong 510631, China. 3. Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. 4. Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. 5. Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Instiute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100101, China. 6. Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address: tanchanglianxy@aliyun.com. 7. Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Medical Psychological Institute of Central South University, Changsha, Hunan 410011, China. Electronic address: xiongzhaozhu@163.com.
Abstract
BACKGROUND: Default mode network (DMN), central executive network (CEN) and salience network (SN) are the three most important intrinsic networks of the human brain. Recent studies emphasized the importance of the "triple-network model" which illustrated the interactions within and between DMN, CEN and SN in the pathophysiology of psychiatric disorders. However, previous studies of obsessive-compulsive disorder (OCD) just explored the altered connectivity within these networks while neglected the coupling between them. Hence, the present study was designed to fill this research gap. METHODS: Resting-state functional magnetic resonance imaging (fMRI) data from 35 OCD patients and 32 healthy controls (HCs) were acquired. Independent component analysis (ICA) was used to extract sub-networks of the DMN, CEN, and SN. Functional connectivity (FC) values within and between these networks were measured. RESULTS: OCD patients had increased FC within several DMN, CEN, and SN subsystems. In addition, OCD patients demonstrated aberrant functional interactions between the SN and anterior DMN (aDMN) as well as between the SN and the dorsal CEN (dCEN), and the interaction between the SN and dCEN significantly correlated with trait anxiety level in the OCD group. LIMITATION: Lack of the assessments of cognitive functions is the main limitation of the present study. CONCLUSIONS: Not only impaired coupling within the brain core intrinsic large-scale networks, but also coupling between large-scale neurocognitive networks, which reflect the difficulties in switching between task-negative and task-positive processing modes are involved in the neurobiological mechanism of OCD.
BACKGROUND: Default mode network (DMN), central executive network (CEN) and salience network (SN) are the three most important intrinsic networks of the human brain. Recent studies emphasized the importance of the "triple-network model" which illustrated the interactions within and between DMN, CEN and SN in the pathophysiology of psychiatric disorders. However, previous studies of obsessive-compulsive disorder (OCD) just explored the altered connectivity within these networks while neglected the coupling between them. Hence, the present study was designed to fill this research gap. METHODS: Resting-state functional magnetic resonance imaging (fMRI) data from 35 OCDpatients and 32 healthy controls (HCs) were acquired. Independent component analysis (ICA) was used to extract sub-networks of the DMN, CEN, and SN. Functional connectivity (FC) values within and between these networks were measured. RESULTS:OCDpatients had increased FC within several DMN, CEN, and SN subsystems. In addition, OCDpatients demonstrated aberrant functional interactions between the SN and anterior DMN (aDMN) as well as between the SN and the dorsal CEN (dCEN), and the interaction between the SN and dCEN significantly correlated with trait anxiety level in the OCD group. LIMITATION: Lack of the assessments of cognitive functions is the main limitation of the present study. CONCLUSIONS: Not only impaired coupling within the brain core intrinsic large-scale networks, but also coupling between large-scale neurocognitive networks, which reflect the difficulties in switching between task-negative and task-positive processing modes are involved in the neurobiological mechanism of OCD.
Authors: H Blair Simpson; Rachel Marsh; Tracey C Shi; David Pagliaccio; Marilyn Cyr Journal: Neuropsychopharmacology Date: 2021-01-14 Impact factor: 7.853
Authors: Ariel A Gonzalez; Katherine L Bottenhorn; Jessica E Bartley; Timothy Hayes; Michael C Riedel; Taylor Salo; Elsa I Bravo; Rosalie Odean; Alina Nazareth; Robert W Laird; Matthew T Sutherland; Eric Brewe; Shannon M Pruden; Angela R Laird Journal: NPJ Sci Learn Date: 2019-11-01
Authors: Rajan Kashyap; Goi Khia Eng; Sagarika Bhattacharjee; Bhanu Gupta; Roger Ho; Cyrus S H Ho; Melvyn Zhang; Rathi Mahendran; Kang Sim; S H Annabel Chen Journal: Sci Rep Date: 2021-01-14 Impact factor: 4.379