Literature DB >> 28740600

Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor.

Laura M Bohn1, Jeffrey Aubé2.   

Abstract

The discovery and characterization of two classes of kappa opioid receptor agonists that are biased for G protein over βarrestin signaling are described.

Entities:  

Keywords:  G protein-coupled receptors; biased ligands; functional selectivity; kappa opioid receptor agonists; βArrestin

Year:  2017        PMID： 28740600      PMCID： PMC5512133          DOI： 10.1021/acsmedchemlett.7b00224

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  47 in total

Review 1.  Structural mechanism of GPCR-arrestin interaction: recent breakthroughs.

Authors:  Ji Young Park; Su Youn Lee; Hee Ryung Kim; Min-Duk Seo; Ka Young Chung
Journal:  Arch Pharm Res       Date:  2016-01-29       Impact factor: 4.946

Review 2.  How many drug targets are there?

Authors:  John P Overington; Bissan Al-Lazikani; Andrew L Hopkins
Journal:  Nat Rev Drug Discov       Date:  2006-12       Impact factor: 84.694

3.  Discovery of a structurally novel opioid kappa-agonist derived from 4,5-epoxymorphinan.

Authors:  H Nagase; J Hayakawa; K Kawamura; K Kawai; Y Takezawa; H Matsuura; C Tajima; T Endo
Journal:  Chem Pharm Bull (Tokyo)       Date:  1998-02       Impact factor: 1.645

4.  A simple method for quantifying functional selectivity and agonist bias.

Authors:  Terry Kenakin; Christian Watson; Vanessa Muniz-Medina; Arthur Christopoulos; Steven Novick
Journal:  ACS Chem Neurosci       Date:  2011-12-20       Impact factor: 4.418

5.  Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade.

Authors:  L M Bohn; M M Belcheva; C J Coscia
Journal:  J Neurochem       Date:  2000-02       Impact factor: 5.372

6.  Identification of novel functionally selective κ-opioid receptor scaffolds.

Authors:  Kate L White; Alex P Scopton; Marie-Laure Rives; Ruslan V Bikbulatov; Prabhakar R Polepally; Peter J Brown; Terrance Kenakin; Jonathan A Javitch; Jordan K Zjawiony; Bryan L Roth
Journal:  Mol Pharmacol       Date:  2013-10-10       Impact factor: 4.436

7.  Enhanced morphine analgesia in mice lacking beta-arrestin 2.

Authors:  L M Bohn; R J Lefkowitz; R R Gainetdinov; K Peppel; M G Caron; F T Lin
Journal:  Science       Date:  1999-12-24       Impact factor: 47.728

Review 8.  Allostery and Biased Agonism at Class B G Protein-Coupled Receptors.

Authors:  Denise Wootten; Laurence J Miller; Cassandra Koole; Arthur Christopoulos; Patrick M Sexton
Journal:  Chem Rev       Date:  2016-04-04       Impact factor: 60.622

Review 9.  GPCR Dynamics: Structures in Motion.

Authors:  Naomi R Latorraca; A J Venkatakrishnan; Ron O Dror
Journal:  Chem Rev       Date:  2016-09-13       Impact factor: 60.622

Review 10.  The structure and function of G-protein-coupled receptors.

Authors:  Daniel M Rosenbaum; Søren G F Rasmussen; Brian K Kobilka
Journal:  Nature       Date:  2009-05-21       Impact factor: 49.962
View more
  14 in total

Review 1.  A Biased View of μ-Opioid Receptors?

Authors:  Alexandra E Conibear; Eamonn Kelly
Journal:  Mol Pharmacol       Date:  2019-06-07       Impact factor: 4.436

Review 2.  The Kappa Opioid Receptor: A Promising Therapeutic Target for Multiple Pathologies.

Authors:  Martin L Dalefield; Brittany Scouller; Rabia Bibi; Bronwyn M Kivell
Journal:  Front Pharmacol       Date:  2022-06-20       Impact factor: 5.988

3.  Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine.

Authors:  Shane W Kaski; Allison N White; Joshua D Gross; Kristen R Trexler; Kim Wix; Aubrie A Harland; Thomas E Prisinzano; Jeffrey Aubé; Steven G Kinsey; Terry Kenakin; David P Siderovski; Vincent Setola
Journal:  J Pharmacol Exp Ther       Date:  2019-09-06       Impact factor: 4.030

4.  Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity.

Authors:  Michael L Martini; Caroline Ray; Xufen Yu; Jing Liu; Vladimir M Pogorelov; William C Wetsel; Xi-Ping Huang; John D McCorvy; Marc G Caron; Jian Jin
Journal:  ACS Chem Neurosci       Date:  2019-08-20       Impact factor: 4.418

5.  Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior.

Authors:  Joshua D Gross; Shane W Kaski; Karl T Schmidt; Elizabeth S Cogan; Kristen M Boyt; Kim Wix; Adam B Schroer; Zoe A McElligott; David P Siderovski; Vincent Setola
Journal:  Neuropsychopharmacology       Date:  2019-05-29       Impact factor: 7.853

6.  Biased Opioid Receptor Ligands: Gain without Pain.

Authors:  Tyler C Beck; Thomas A Dix; Russell A Norris
Journal:  Trends Endocrinol Metab       Date:  2020-09-14       Impact factor: 12.015

Review 7.  Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors.

Authors:  Jolien De Neve; Thomas M A Barlow; Dirk Tourwé; Frédéric Bihel; Frédéric Simonin; Steven Ballet
Journal:  RSC Med Chem       Date:  2021-04-21

8.  Fundamentals of the Dynorphins/Kappa Opioid Receptor System: From Distribution to Signaling and Function.

Authors:  Catherine Cahill; Hugo A Tejeda; Mariana Spetea; Chongguang Chen; Lee-Yuan Liu-Chen
Journal:  Handb Exp Pharmacol       Date:  2022

Review 9.  Kappa Opioid Receptor Mediated Differential Regulation of Serotonin and Dopamine Transporters in Mood and Substance Use Disorder.

Authors:  Durairaj Ragu Varman; Lankupalle D Jayanthi; Sammanda Ramamoorthy
Journal:  Handb Exp Pharmacol       Date:  2022

10.  Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake.

Authors:  Daniel W Bloodgood; J Andrew Hardaway; Christina M Stanhope; Dipanwita Pati; Melanie M Pina; Sofia Neira; Shivani Desai; Kristen M Boyt; Richard D Palmiter; Thomas L Kash
Journal:  Mol Psychiatry       Date:  2020-02-25       Impact factor: 13.437
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.