Beth Brooks1, Kristin Knight2. 1. a Registered Audiologist , British Columbia's Children's Hospital , Vancouver , BC , Canada and. 2. b Department of Pediatric Audiology, Child Development and Rehabilitation Center , Doernbecher Children's Hospital, Oregon Health and Science University , Portland , OR , USA.
Abstract
OBJECTIVE: To review the prevalence, mechanisms, clinical presentation, risk factors and implications of platinum-induced ototoxicity in paediatric cancer patients based on published evidence, discuss options for monitoring hearing in young children during treatment and review long-term follow-up guidelines. DESIGN: Narrative literature review. RESULTS: Children treated with cisplatin are at high risk of hearing loss and early, accurate identification of ototoxicity is important for medical decision making and hearing rehabilitation. Challenges of monitoring hearing in young children during cancer treatment and options for monitoring hearing are discussed. CONCLUSION: Hearing loss has important consequences for the survivors of childhood cancer including communication, learning, cognition and quality of life. Due to the presentation and configuration of ototoxic hearing loss, the test frequencies that are prioritised and the sequence of testing may differ from standard paediatric hearing evaluations. Hearing should be monitored during treatment and after completion of therapy.
OBJECTIVE: To review the prevalence, mechanisms, clinical presentation, risk factors and implications of platinum-induced ototoxicity in paediatric cancerpatients based on published evidence, discuss options for monitoring hearing in young children during treatment and review long-term follow-up guidelines. DESIGN: Narrative literature review. RESULTS:Children treated with cisplatin are at high risk of hearing loss and early, accurate identification of ototoxicity is important for medical decision making and hearing rehabilitation. Challenges of monitoring hearing in young children during cancer treatment and options for monitoring hearing are discussed. CONCLUSION:Hearing loss has important consequences for the survivors of childhood cancer including communication, learning, cognition and quality of life. Due to the presentation and configuration of ototoxic hearing loss, the test frequencies that are prioritised and the sequence of testing may differ from standard paediatric hearing evaluations. Hearing should be monitored during treatment and after completion of therapy.
Authors: Andrew M Breglio; Aaron E Rusheen; Eric D Shide; Katharine A Fernandez; Katie K Spielbauer; Katherine M McLachlin; Matthew D Hall; Lauren Amable; Lisa L Cunningham Journal: Nat Commun Date: 2017-11-21 Impact factor: 14.919
Authors: Pattarawadee Prayuenyong; John A Taylor; Stephanie E Pearson; Rachel Gomez; Poulam M Patel; Deborah A Hall; Anand V Kasbekar; David M Baguley Journal: Front Oncol Date: 2018-09-25 Impact factor: 6.244
Authors: E Clemens; B Brooks; A C H de Vries; M van Grotel; M M van den Heuvel-Eibrink; B Carleton Journal: PLoS One Date: 2019-02-14 Impact factor: 3.240