Anna Heidbreder1, Ambra Stefani2, Elisabeth Brandauer2, Ruth Steiger3, Christian Kremser4, Elke R Gizewski3, Peter Young5, Werner Poewe2, Birgit Högl2, Christoph Scherfler6. 1. Department of Neurology, Medical University Innsbruck, Innsbruck, Austria; Department of Neurology, Division of Sleep Medicine and Neuromuscular Disorders, University Hospital Muenster, Muenster, Germany. 2. Department of Neurology, Medical University Innsbruck, Innsbruck, Austria. 3. Neuroimaging Research Core Facility, Medical University of Innsbruck, Innsbruck, Austria; Department of Neuroradiology, Medical University Innsbruck, Innsbruck, Austria. 4. Neuroimaging Research Core Facility, Medical University of Innsbruck, Innsbruck, Austria. 5. Department of Neurology, Division of Sleep Medicine and Neuromuscular Disorders, University Hospital Muenster, Muenster, Germany. 6. Department of Neurology, Medical University Innsbruck, Innsbruck, Austria; Neuroimaging Research Core Facility, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: christoph.scherfler@i-med.ac.at.
Abstract
OBJECTIVE: This study aimed to determine whether voxel-based analysis of T1 weighted magnetic resonance imaging (MRI) and diffusion tensor imaging is able to detect alterations of gray and white matter morphometry as well as measures of mean diffusivity and fractional anisotropy in patients with non-rapid eye movement parasomnia. METHODS: 3 Tesla MRI was performed in 14 drug-free, polysomnography-confirmed adult patients with non-rapid eye movement parasomnia (age: 29 ± 4.2 years; disease duration 19.2 ± 7.7 years) and 14 healthy subjects, matched for age and gender. Statistical parametric mapping was applied to objectively identify focal changes of MRI parameters throughout the entire brain volume. RESULTS: Statistical parametric mapping localized significant decreases of gray matter volume in the left dorsal posterior cingulate cortex (BA23) and posterior midcingulate cortex (BA24) in patients with non-rapid eye movement parasomnias compared to the control group (p < 0.001, corrected for multiple comparisons). No significant differences of mean diffusivity and fractional anisotropy measures were found between the non-rapid eye movement parasomnia group and the healthy control group. CONCLUSIONS: Recently, the simultaneous co-existence of arousal or wakefulness originating from the motor and cingulate cortices and persistent sleep in associative cortical regions was suggested as a functional framework of somnambulism. Gray matter volume decline in the dorsal posterior and posterior midcingulate cortex reported in this study might represent the neuroanatomical substrate for this condition.
OBJECTIVE: This study aimed to determine whether voxel-based analysis of T1 weighted magnetic resonance imaging (MRI) and diffusion tensor imaging is able to detect alterations of gray and white matter morphometry as well as measures of mean diffusivity and fractional anisotropy in patients with non-rapid eye movement parasomnia. METHODS: 3 Tesla MRI was performed in 14 drug-free, polysomnography-confirmed adult patients with non-rapid eye movement parasomnia (age: 29 ± 4.2 years; disease duration 19.2 ± 7.7 years) and 14 healthy subjects, matched for age and gender. Statistical parametric mapping was applied to objectively identify focal changes of MRI parameters throughout the entire brain volume. RESULTS: Statistical parametric mapping localized significant decreases of gray matter volume in the left dorsal posterior cingulate cortex (BA23) and posterior midcingulate cortex (BA24) in patients with non-rapid eye movement parasomnias compared to the control group (p < 0.001, corrected for multiple comparisons). No significant differences of mean diffusivity and fractional anisotropy measures were found between the non-rapid eye movement parasomnia group and the healthy control group. CONCLUSIONS: Recently, the simultaneous co-existence of arousal or wakefulness originating from the motor and cingulate cortices and persistent sleep in associative cortical regions was suggested as a functional framework of somnambulism. Gray matter volume decline in the dorsal posterior and posterior midcingulate cortex reported in this study might represent the neuroanatomical substrate for this condition.
Authors: Markus Ramm; Alexandra Urbanek; Annette Failing; Peter Young; Christoph Scherfler; Birgit Högl; Anna Heidbreder Journal: J Clin Sleep Med Date: 2020-10-15 Impact factor: 4.062