Markus Ramm1,2, Alexandra Urbanek1, Annette Failing3, Peter Young4, Christoph Scherfler5, Birgit Högl5, Anna Heidbreder1,5. 1. Department of Neurology, Institute of Translational Neurology, University Hospital Muenster, Muenster, Germany. 2. Neurobiology and Genetics of Behavior, Department of Psychology and Psychotherapy, Centre for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Witten, Germany. 3. Radprax, Institute for Diagnostics and Research, Muenster, Germany. 4. Department of Neurology, Medical Park Bad Feilnbach Reithofpark, Bad Feilnbach, Germany. 5. Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Abstract
STUDY OBJECTIVES: Reduced gray matter volume in the posterior cingulate cortex (PCC) has recently been found in patients with non-rapid eye movement (NREM) parasomnia, providing a neuroanatomical substrate for the arousal state dissociation. It remains unclear whether PCC changes in NREM parasomnias might also play a role in cognitive or affective dysfunction in these patients. The aim of this exploratory study was to investigate neurobehavioral correlates of PCC abnormalities in patients with NREM parasomnia. METHODS: The Reinforcement Sensitivity Theory of Personality Questionnaire and the Stress Coping Questionnaire were used to assess personality and stress coping in 15 patients with NREM parasomnia and 15 age- and sex-matched healthy controls. Patients' left PCC gray matter volume was quantified with voxel-based morphometry on 3 Tesla T1-weighted magnetic resonance imaging data. RESULTS: In the Reinforcement Sensitivity Theory of Personality Questionnaire, increased trait reactivity of the behavioral inhibition system and goal-drive persistence contributed most to the discrimination of patients and controls. In the Stress Coping Questionnaire, patients showed an increased negative coping trait (ie, anxious rumination) related to an increase in adjusted left PCC volume. CONCLUSIONS: The results suggest subclinical behavioral abnormalities in patients with NREM parasomnias. Such traits might trigger maladaptive emotion regulation processes related to a relative PCC volume increase. The findings encourage further longitudinal studies on this topic, which can provide insights into the causal relations underlying the PCC volume-behavior correlation. Such future studies will have a more direct implication for the clinical management of patients with NREM parasomnias.
STUDY OBJECTIVES: Reduced gray matter volume in the posterior cingulate cortex (PCC) has recently been found in patients with non-rapid eye movement (NREM) parasomnia, providing a neuroanatomical substrate for the arousal state dissociation. It remains unclear whether PCC changes in NREM parasomnias might also play a role in cognitive or affective dysfunction in these patients. The aim of this exploratory study was to investigate neurobehavioral correlates of PCC abnormalities in patients with NREM parasomnia. METHODS: The Reinforcement Sensitivity Theory of Personality Questionnaire and the Stress Coping Questionnaire were used to assess personality and stress coping in 15 patients with NREM parasomnia and 15 age- and sex-matched healthy controls. Patients' left PCC gray matter volume was quantified with voxel-based morphometry on 3 Tesla T1-weighted magnetic resonance imaging data. RESULTS: In the Reinforcement Sensitivity Theory of Personality Questionnaire, increased trait reactivity of the behavioral inhibition system and goal-drive persistence contributed most to the discrimination of patients and controls. In the Stress Coping Questionnaire, patients showed an increased negative coping trait (ie, anxious rumination) related to an increase in adjusted left PCC volume. CONCLUSIONS: The results suggest subclinical behavioral abnormalities in patients with NREM parasomnias. Such traits might trigger maladaptive emotion regulation processes related to a relative PCC volume increase. The findings encourage further longitudinal studies on this topic, which can provide insights into the causal relations underlying the PCC volume-behavior correlation. Such future studies will have a more direct implication for the clinical management of patients with NREM parasomnias.
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