Anna Katharina Kösters1, Bergita Ganse1, Boyko Gueorguiev2, Kajetan Klos3, Ali Modabber4, Sven Nebelung5, Bong-Sung S Kim6, Matthias Knobe7. 1. Department of Orthopaedic Trauma, University of Aachen Medical Center, 30 Pauwelsstreet, 52074, Aachen, Germany. 2. AO Research Institute Davos, Davos, Switzerland. 3. Department of Foot and Ankle Surgery, Catholic Hospital Mainz, Mainz, Germany. 4. Department of Oral and Maxillofacial Surgery, University of Aachen Medical Center, Aachen, Germany. 5. Department of Radiology, University of Aachen Medical Center, Aachen, Germany. 6. Department of Plastic Surgery, Reconstructive and Hand Surgery, University of Aachen Medical Center, Aachen, Germany. 7. Department of Orthopaedic Trauma, University of Aachen Medical Center, 30 Pauwelsstreet, 52074, Aachen, Germany. mknobe@ukaachen.de.
Abstract
PURPOSE: Low-intensity pulsed ultrasound (LIPUS) has been shown to accelerate bone healing and is considered to increase blood flow. The aim of this study was to assess changes in micro-circulation of the foots' soft tissue in response to LIPUS intervention. We hypothesised improved micro-circulation in response to LIPUS. METHODS: Micro-circulation was assessed in 2 mm and 8 mm-deep skin of 50 healthy volunteers using non-invasive laser-doppler spectrophotometry (O2C-device). Measurements were performed before LIPUS-intervention (pre), directly after intervention (post) and 20, 40 and 60 minutes after LIPUS. RESULTS: All parameter of micro-circulation increased directly after LIPUS intervention at 8 mm depth. Participants with a low pre-intervention flow showed the largest changes (p < 0.001) with an increased post-flow of 38%. SO2 levels increased significantly after intervention (p = 0.045) and decreased after 60 minutes in comparison to pre-intervention status. rHb levels after 60 min were significantly higher in comparison to pre-intervention levels. CONCLUSION: In healthy volunteers, low-intensity pulsed ultrasound led to significant short-term changes in microcirculation of the foot. Younger subjects with a low pre-flow level and smokers showed a higher potential to increase blood flow after LIPUS.
PURPOSE: Low-intensity pulsed ultrasound (LIPUS) has been shown to accelerate bone healing and is considered to increase blood flow. The aim of this study was to assess changes in micro-circulation of the foots' soft tissue in response to LIPUS intervention. We hypothesised improved micro-circulation in response to LIPUS. METHODS: Micro-circulation was assessed in 2 mm and 8 mm-deep skin of 50 healthy volunteers using non-invasive laser-doppler spectrophotometry (O2C-device). Measurements were performed before LIPUS-intervention (pre), directly after intervention (post) and 20, 40 and 60 minutes after LIPUS. RESULTS: All parameter of micro-circulation increased directly after LIPUS intervention at 8 mm depth. Participants with a low pre-intervention flow showed the largest changes (p < 0.001) with an increased post-flow of 38%. SO2 levels increased significantly after intervention (p = 0.045) and decreased after 60 minutes in comparison to pre-intervention status. rHb levels after 60 min were significantly higher in comparison to pre-intervention levels. CONCLUSION: In healthy volunteers, low-intensity pulsed ultrasound led to significant short-term changes in microcirculation of the foot. Younger subjects with a low pre-flow level and smokers showed a higher potential to increase blood flow after LIPUS.
Authors: Michael Coords; Eric Breitbart; David Paglia; Nikolas Kappy; Ankur Gandhi; Jessica Cottrell; Natalie Cedeno; Neill Pounder; J Patrick O'Connor; Sheldon S Lin Journal: J Orthop Res Date: 2010-09-30 Impact factor: 3.494
Authors: John Bennet Carow; Juliane Carow; Boyko Gueorguiev; Kajetan Klos; Christian Herren; Miguel Pishnamaz; Christian David Weber; Sven Nebelung; Bong-Sung Kim; Matthias Knobe Journal: Int Orthop Date: 2018-06-22 Impact factor: 3.075