Literature DB >> 2873526

Biotransformation of amitriptyline in man: interaction with phenothiazines.

S Vandel, M Sandoz, B Vandel, B Bonin, G Allers, R Volmat.   

Abstract

The biotransformation modification of amitriptyline by phenothiazines has been studied in 65 depressive inpatients. Thirty-four of them were treated with oral amitriptyline and 31 with a combination of amitriptyline and phenothiazine. Urinary and plasmatic results showed a decrease in hydroxylated metabolites of amitriptyline (OHAMTc and OHAMT) in patients with added phenothiazine.

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Year:  1986        PMID: 2873526     DOI: 10.1159/000118235

Source DB:  PubMed          Journal:  Neuropsychobiology        ISSN: 0302-282X            Impact factor:   2.328


  2 in total

1.  Amitriptyline: linear or nonlinear kinetics in every day practice?

Authors:  S Vandel; G Bertschy; B Vandel; G Allers; R Volmat
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

2.  Minor and clinically non-significant interaction between toloxatone and amitriptyline.

Authors:  S Vandel; G Bertschy; M C Perault; M Sandoz; S Bouquet; R Chakroun; S Guibert; B Vandel
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

  2 in total

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