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Literature DB >> 2612556

Amitriptyline: linear or nonlinear kinetics in every day practice?

S Vandel¹, G Bertschy, B Vandel, G Allers, R Volmat.

Abstract

The linearity of the (AMT) kinetics of amitriptyline has been tested in 135 depressed dosed twice daily by measuring plasma. Their (AMT) and nortriptyline (NT) levels under steady-state conditions. The AMT concentration/dose ratios at low and high dosages were not significantly different and there was a linear relationship between the dose ratios and the concentration ratios. No change in the metabolic ratio (AMT/NT) was observed between the two dosages. Although the results are consistent with linear AMT kinetics, there may have been nonlinear kinetics in some patients as the ratio between the concentration/dose ratios in them at low and high dosages was greater than one. Those patients were characterized by a low concentration/dose ratio at low dosage. No clinical adverse effect appeared in the study.

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Year: 1989 PMID： 2612556 DOI： 10.1007/bf00562551

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

21 in total

1. Substantial rise in sparteine metabolic ratio during haloperidol treatment.

Authors: L F Gram; D Debruyne; V Caillard; J P Boulenger; J Lacotte; M Moulin; E Zarifian
Journal: Br J Clin Pharmacol Date: 1989-02 Impact factor: 4.335

2. Clinical response and plasma concentration of amitriptyline and its metabolite nortriptyline.

Authors: S Vandel; B Vandel; M Sandoz; G Allers; P Bechtel; R Volmat
Journal: Eur J Clin Pharmacol Date: 1978-11-27 Impact factor: 2.953

Review 3. Tricyclic antidepressants--blood level measurements and clinical outcome: an APA Task Force report. Task Force on the Use of Laboratory Tests in Psychiatry.

Authors:
Journal: Am J Psychiatry Date: 1985-02 Impact factor: 18.112

2. Nonlinear kinetics of nortriptyline in relation to nortriptyline clearance as observed during therapeutic drug monitoring.

Authors: M Jerling; G Alván
Journal: Eur J Clin Pharmacol Date: 1994 Impact factor: 2.953

2 in total

Amitriptyline: linear or nonlinear kinetics in every day practice?

1. Substantial rise in sparteine metabolic ratio during haloperidol treatment.

2. Clinical response and plasma concentration of amitriptyline and its metabolite nortriptyline.

Review 3. Tricyclic antidepressants--blood level measurements and clinical outcome: an APA Task Force report. Task Force on the Use of Laboratory Tests in Psychiatry.

4. Dose-dependent kinetics of imipramine in elderly patients.

5. Debrisoquine oxidative phenotyping and psychiatric drug treatment.

6. The nonlinear kinetics of desipramine and 2-hydroxydesipramine in plasma.

7. Plasma levels, psychophysiological variables, and clinical response to amitriptyline.

8. E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylation.

9. Nonlinear desipramine kinetics: prevalence and importance.

10. Biotransformation of amitriptyline in man: interaction with phenothiazines.

1. Nonlinear kinetics of nortriptyline in every day practice.

2. Nonlinear kinetics of nortriptyline in relation to nortriptyline clearance as observed during therapeutic drug monitoring.