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Literature DB >> 28726106

Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad Bufo bufo-New agonists of ionotropic γ-aminobutyric acid receptors.

D S Lebedev¹, I A Ivanov², E V Kryukova², V G Starkov², V I Tsetlin², Yu N Utkin^2,3.

Abstract

Compounds activating γ-aminobutyric acid type A receptor were isolated from the toad Bufo bufo venom as a result of chromatographic separation. Analysis of the structure of these compounds by mass spectrometry and nuclear magnetic resonance showed that they are arginine derivatives of dicarboxylic acids and represent suberylarginine, pimeloylarginine, and adipoylarginine.

Entities: Chemical Species

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Year: 2017 PMID： 28726106 DOI： 10.1134/S1607672917030127

Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788

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References

14 in total

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Authors: K Shimada; K Ohishi; H Fukunaga; J S Ro; T Nambara
Journal: J Pharmacobiodyn Date: 1985-12

Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad Bufo bufo-New agonists of ionotropic γ-aminobutyric acid receptors.

1. Activation of cerebellar granule cells GABA(A) receptors by guanidinoacetate.

Review 2. Bufadienolides from animal and plant sources.

3. Structure-activity relationship of bufotoxins and related compounds for the inhibition of Na+, K+ -adenosine triphosphatase.

4. Comparison of toad venoms from different Bufo species by HPLC and LC-DAD-MS/MS.

Review 5. Muscimol as an ionotropic GABA receptor agonist.

6. Activation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism.

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8. Crystal structure of a human GABAA receptor.

9. Resibufogenin and cinobufagin activate central neurons through an ouabain-like action.

10. A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans.