Literature DB >> 24473816

Muscimol as an ionotropic GABA receptor agonist.

Graham A R Johnston1.   

Abstract

Muscimol, a psychoactive isoxazole from Amanita muscaria and related mushrooms, has proved to be a remarkably selective agonist at ionotropic receptors for the inhibitory neurotransmitter GABA. This historic overview highlights the discovery and development of muscimol and related compounds as a GABA agonist by Danish and Australian neurochemists. Muscimol is widely used as a ligand to probe GABA receptors and was the lead compound in the development of a range of GABAergic agents including nipecotic acid, tiagabine, 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol, (Gaboxadol(®)) and 4-PIOL.

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Year:  2014        PMID： 24473816     DOI： 10.1007/s11064-014-1245-y

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  45 in total

1.  Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds.

Authors:  P Krogsgaard-Larsen; G A Johnston
Journal:  J Neurochem       Date:  1975-12       Impact factor: 5.372

2.  Differential effects of nipecotic acid and 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol on extracellular gamma-aminobutyrate levels in rat thalamus.

Authors:  G Juhász; K A Kékesi; G Nyitrai; A Dobolyi; P Krogsgaard-Larsen; A Schousboe
Journal:  Eur J Pharmacol       Date:  1997-07-23       Impact factor: 4.432

3.  Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors.

Authors:  Nasiara Karim; Petrine Wellendorph; Nathan Absalom; Line Haunstrup Bang; Marianne Lerbech Jensen; Maja Michelle Hansen; Ho Joon Lee; Graham A R Johnston; Jane R Hanrahan; Mary Chebib
Journal:  Biochem Pharmacol       Date:  2012-05-29       Impact factor: 5.858

4.  Selective inhibitors of glial GABA uptake: synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues.

Authors:  E Falch; J Perregaard; B FrŁlund; B SŁkilde; A Buur; L M Hansen; K Frydenvang; L Brehm; T Bolvig; O M Larsson; C Sanchez; H S White; A Schousboe; P Krogsgaard-Larsen
Journal:  J Med Chem       Date:  1999-12-30       Impact factor: 7.446

Review 5.  GABA transport inhibitors and seizure protection: the past and future.

Authors:  Arne Schousboe; Karsten K Madsen; H Steve White
Journal:  Future Med Chem       Date:  2011-02       Impact factor: 3.808

6.  Use of 3H-muscimol for GABA receptor studies.

Authors:  S R Snodgrass
Journal:  Nature       Date:  1978-06-01       Impact factor: 49.962

7.  Inhibition of spinal neurons by glycine.

Authors:  D R Curtis; L Hösli; G A Johnston
Journal:  Nature       Date:  1967-09-30       Impact factor: 49.962

8.  4-aminotetrolic acid: new conformational-restricted analogue of -aminobutyric acid.

Authors:  P M Beart; D R Curtis; G A Johnston
Journal:  Nat New Biol       Date:  1971-11-17

9.  Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABA A antagonists.

Authors:  Bente Frølund; Lena Tagmose; Anne T Jørgensen; Uffe Kristiansen; Tine B Stensbøl; Tommy Liljefors; Povl Krogsgaard-Larsen
Journal:  Eur J Med Chem       Date:  2003-04       Impact factor: 6.514

10.  Partial GABAA receptor agonists. Synthesis and in vitro pharmacology of a series of nonannulated analogs of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol.

Authors:  B Frølund; U Kristiansen; L Brehm; A B Hansen; P Krogsgaard-Larsen; E Falch
Journal:  J Med Chem       Date:  1995-08-18       Impact factor: 7.446
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  23 in total

1.  MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity.

Authors:  Jean-Pierre Rosso; Jürgen R Schwarz; Marcelo Diaz-Bustamante; Brigitte Céard; José M Gutiérrez; Matthias Kneussel; Olaf Pongs; Frank Bosmans; Pierre E Bougis
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-09       Impact factor: 11.205

2.  Pharmacological characterization of the excitatory 'Cys-loop' GABA receptor family in Caenorhabditis elegans.

Authors:  Georgina C B Nicholl; Ali K Jawad; Robert Weymouth; Haoming Zhang; Asim A Beg
Journal:  Br J Pharmacol       Date:  2017-03-10       Impact factor: 8.739

3.  Location of the Mesopontine Neurons Responsible for Maintenance of Anesthetic Loss of Consciousness.

Authors:  Anne Minert; Shai-Lee Yatziv; Marshall Devor
Journal:  J Neurosci       Date:  2017-08-16       Impact factor: 6.167

4.  Corticostriatal interactions in the generation of tic-like behaviors after local striatal disinhibition.

Authors:  Vladimir Pogorelov; Meiyu Xu; Haleigh R Smith; Gordon F Buchanan; Christopher Pittenger
Journal:  Exp Neurol       Date:  2015-01-15       Impact factor: 5.330

5.  Perineuronal Nets in the Adult Sensory Cortex Are Necessary for Fear Learning.

Authors:  Sunayana B Banerjee; Vanessa A Gutzeit; Justin Baman; Hadj S Aoued; Nandini K Doshi; Robert C Liu; Kerry J Ressler
Journal:  Neuron       Date:  2017-06-22       Impact factor: 17.173

Review 6.  Unsaturated Analogues of the Neurotransmitter GABA: trans-4-Aminocrotonic, cis-4-Aminocrotonic and 4-Aminotetrolic Acids.

Authors:  Graham A R Johnston
Journal:  Neurochem Res       Date:  2015-05-27       Impact factor: 3.996

7.  Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad Bufo bufo-New agonists of ionotropic γ-aminobutyric acid receptors.

Authors:  D S Lebedev; I A Ivanov; E V Kryukova; V G Starkov; V I Tsetlin; Yu N Utkin
Journal:  Dokl Biochem Biophys       Date:  2017-07-20       Impact factor: 0.788

8.  Biological activities of two polypore macrofungi (Basidiomycota) and characterization of their compounds using HPLC-DAD and LC-ESI-MS/MS.

Authors:  Samaneh Chaharmiri Dokhaharani; Masoomeh Ghobad-Nejhad; Hamid Moghimi; Abbas Farazmand; Hossein Rahmani
Journal:  Folia Microbiol (Praha)       Date:  2021-06-13       Impact factor: 2.099

9.  Convection-Enhanced Delivery of Muscimol Into the Bilateral Subthalamic Nuclei of Nonhuman Primates.

Authors:  John D Heiss; Stuart Walbridge; Davis P Argersinger; Christopher S Hong; Abhik Ray-Chaudhury; Russell R Lonser; W Jeffrey Elias; Kareem A Zaghloul
Journal:  Neurosurgery       Date:  2019-06-01       Impact factor: 4.654

Review 10.  The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus.

Authors:  H Elliott Albers; James C Walton; Karen L Gamble; John K McNeill; Daniel L Hummer
Journal:  Front Neuroendocrinol       Date:  2016-11-25       Impact factor: 8.606
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