Literature DB >> 28726101

Eukaryotic elongation factor 2 kinase activation in M. soleus under 14-day hindlimb unloading of rats.

Y N Lomonosova1, S P Belova2, T M Mirzoev2, I B Kozlovskaya2, B S Shenkman2.   

Abstract

Functional unloading of m. soleus of male Wistar rats was found to cause a reduction in protein synthesis. The level of phosphorylation of the translation elongation factor 2 (eEF2) and the eEF2 kinase (eEF2k) activity in m. soleus after 14 days of unloading were assessed. Rats were divided into the control group (C) and the group with hindlimb unloading for 14 days (HU14). The level of eEF2 phosphorylation in group HU14 was 80%, whereas in the control is was 40%. The indices of eEF2k expression and protein content in group HU14 increased compared to group C.

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Year:  2017        PMID： 28726101     DOI： 10.1134/S1607672917030048

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  14 in total

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Authors:  Gareth J Browne; Christopher G Proud
Journal:  Eur J Biochem       Date:  2002-11

2.  Phosphorylation of elongation factor and its kinase expression in Rat m. soleus under early stage of hindlimb unloading.

Authors:  A M Krasniy; E A Lysenko; I B Kozlovskaya; B S Shenkman; Y N Lomonosova
Journal:  Dokl Biochem Biophys       Date:  2014-01-03       Impact factor: 0.788

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Authors:  D B Thomason; R B Biggs; F W Booth
Journal:  Am J Physiol       Date:  1989-08

4.  Regulation of translation factors during hindlimb unloading and denervation of skeletal muscle in rats.

Authors:  T A Hornberger; R B Hunter; S C Kandarian; K A Esser
Journal:  Am J Physiol Cell Physiol       Date:  2001-07       Impact factor: 4.249

5.  Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men.

Authors:  Adam J Rose; Christa Broholm; Kristian Kiillerich; Stephen G Finn; Christopher G Proud; Mark H Rider; Erik A Richter; Bente Kiens
Journal:  J Physiol       Date:  2005-10-06       Impact factor: 5.182

6.  Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

Authors:  X Wang; W Li; M Williams; N Terada; D R Alessi; C G Proud
Journal:  EMBO J       Date:  2001-08-15       Impact factor: 11.598

7.  Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle.

Authors:  Lisa Miranda; Sandrine Horman; Isabelle De Potter; Louis Hue; Jørgen Jensen; Mark H Rider
Journal:  Pflugers Arch       Date:  2007-10-24       Impact factor: 3.657

8.  Effect of inactivity and passive stretch on protein turnover in phasic and postural rat muscles.

Authors:  P Loughna; G Goldspink; D F Goldspink
Journal:  J Appl Physiol (1985)       Date:  1986-07

9.  Mechanism of elongation factor 2 (EF-2) inactivation upon phosphorylation. Phosphorylated EF-2 is unable to catalyze translocation.

Authors:  A G Ryazanov; E K Davydova
Journal:  FEBS Lett       Date:  1989-07-17       Impact factor: 4.124

10.  Post-meal responses of elongation factor 2 (eEF2) and adenosine monophosphate-activated protein kinase (AMPK) to leucine and carbohydrate supplements for regulating protein synthesis duration and energy homeostasis in rat skeletal muscle.

Authors:  Gabriel J Wilson; Christopher J Moulton; Peter J Garlick; Tracy G Anthony; Donald K Layman
Journal:  Nutrients       Date:  2012-11-13       Impact factor: 5.717
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  4 in total

1.  Plantar mechanical stimulation attenuates protein synthesis decline in disused skeletal muscle via modulation of nitric oxide level.

Authors:  Sergey A Tyganov; Ekaterina Mochalova; Svetlana Belova; Kristina Sharlo; Sergey Rozhkov; Vitaliy Kalashnikov; Olga Turtikova; Timur Mirzoev; Boris Shenkman
Journal:  Sci Rep       Date:  2021-05-07       Impact factor: 4.379

2.  Sequencing the mosaic genome of Brahman cattle identifies historic and recent introgression including polled.

Authors:  L Koufariotis; B J Hayes; M Kelly; B M Burns; R Lyons; P Stothard; A J Chamberlain; S Moore
Journal:  Sci Rep       Date:  2018-12-10       Impact factor: 4.379

3.  Effects of Plantar Mechanical Stimulation on Anabolic and Catabolic Signaling in Rat Postural Muscle Under Short-Term Simulated Gravitational Unloading.

Authors:  Sergey A Tyganov; Ekaterina P Mochalova; Svetlana P Belova; Kristina A Sharlo; Sergey V Rozhkov; Natalia A Vilchinskaya; Inna I Paramonova; Timur M Mirzoev; Boris S Shenkman
Journal:  Front Physiol       Date:  2019-09-27       Impact factor: 4.566

Review 4.  Muscle Atrophy Induced by Mechanical Unloading: Mechanisms and Potential Countermeasures.

Authors:  Yunfang Gao; Yasir Arfat; Huiping Wang; Nandu Goswami
Journal:  Front Physiol       Date:  2018-03-20       Impact factor: 4.566
  4 in total

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