Shigehiro Karashima1,2, Mitsuhiro Kometani1, Hiromasa Tsujiguchi3, Hiroki Asakura4, Shigeru Nakano5, Mikiya Usukura1, Shunsuke Mori1, Masashi Ohe1, Toshitaka Sawamura1, Rika Okuda1, Akinori Hara3, Toshinari Takamura6, Masakazu Yamagishi7, Hiroyuki Nakamura3, Yoshiyu Takeda1, Takashi Yoneda1,8. 1. a Division of Endocrinology and Metabolism, Kanazawa University Graduate School of Medicine , Kanazawa , Japan. 2. b Internal medicine, Saiseikai Kanazawa Hospital , Kanazawa , Japan. 3. c Department of Public Health, Kanazawa University Graduate School of Medicine , Kanazawa , Japan. 4. d Internal Medicine, Shika Town Togi Hospital, Hakui-gun Shika-machi , Japan. 5. e Internal Medicine, Shika Clinic, Hakui-gun Shika-machi , Japan. 6. f Department of Comprehensive Metabology , Kanazawa University Graduate School of Medicine , Kanazawa , Japan. 7. g Department of Cardiovascular and Internal Medicine , Kanazawa University Graduate School of Medicine , Kanazawa , Japan. 8. h Program Management Office for Paradigms Establishing Center for Fostering Medical Researchers of the Future, Kanazawa University , Kanazawa , Japan.
Abstract
OBJECTIVE: Recent studies have reported a high prevalence of primary aldosteronism (PA) among hypertensive patients. However, few data exist regarding the prevalence of PA in the general population. Therefore, we examined the prevalence of PA in the general population including normotensive subjects. METHODS: Plasma renin activity (ng/mL/hr), plasma aldosterone concentration (pg/mL) and aldosterone renin ratio (ARR) were determined in 309 subjects aged >40 years in Horimatsu and Higashi-Matsuho district, Shika-machi, Ishikawa, Japan. RESULTS: Among them, 195 subjects (78 males, mean age: 62 ± 11 years) did not take antihypertensive agents: 113 normotensive subjects and 82 hypertensive subjects. Under these conditions, 68 subjects (13 males, age 62 ± 10 years) had an ARR >200. In 14 subjects who underwent captopril suppression test, PA was documented in 5 subjects, yielding a minimum prevalence of 2.6% in total subjects (1.8% in normotensive subjects and 3.7% in hypertensive subjects). Interestingly, females subjects demonstrated significant differences in ARR between subjects with age <50 (172 ± 105) and those with age 51-60 (388 ± 531), although there were no differences in male subjects. CONCLUSIONS: These results demonstrate that PA including normotensive subjects exists more commonly than that expected in the general population. We suggest further investigation about the cause and progression of PA associated with sex and aging.
OBJECTIVE: Recent studies have reported a high prevalence of primary aldosteronism (PA) among hypertensivepatients. However, few data exist regarding the prevalence of PA in the general population. Therefore, we examined the prevalence of PA in the general population including normotensive subjects. METHODS: Plasma renin activity (ng/mL/hr), plasma aldosterone concentration (pg/mL) and aldosterone renin ratio (ARR) were determined in 309 subjects aged >40 years in Horimatsu and Higashi-Matsuho district, Shika-machi, Ishikawa, Japan. RESULTS: Among them, 195 subjects (78 males, mean age: 62 ± 11 years) did not take antihypertensive agents: 113 normotensive subjects and 82 hypertensive subjects. Under these conditions, 68 subjects (13 males, age 62 ± 10 years) had an ARR >200. In 14 subjects who underwent captopril suppression test, PA was documented in 5 subjects, yielding a minimum prevalence of 2.6% in total subjects (1.8% in normotensive subjects and 3.7% in hypertensive subjects). Interestingly, females subjects demonstrated significant differences in ARR between subjects with age <50 (172 ± 105) and those with age 51-60 (388 ± 531), although there were no differences in male subjects. CONCLUSIONS: These results demonstrate that PA including normotensive subjects exists more commonly than that expected in the general population. We suggest further investigation about the cause and progression of PA associated with sex and aging.
Entities:
Keywords:
General population; normotensive; prevalence; primary aldosteronism
Authors: Isabella Silins; Anders Sundin; Patrik Nordeman; Mahabuba Jahan; Sergio Estrada; Azita Monazzam; Mark Lubberink; Franklin Aigbirhio; Per Hellman; Gunnar Antoni Journal: Int J Med Sci Date: 2021-03-21 Impact factor: 3.738